GSK-2018682 free base · Synonyms: GSK 2018682 · GSK2018682

GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3…

For research use only. Not for human or veterinary use.

Target LPL Receptor

Research area Inflammation/Immunology

Purity >98% Stock Inquire

Data Sheet SDS COA

GSK-2018682 structure

CAS No.: 1034688-30-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 368.00	BP-01832-100mg	In stock	Get quote
250 mg	USD 728.00	BP-01832-250mg	In stock	Get quote
500 mg	USD 1,080.00	BP-01832-500mg	In stock	Get quote
1 g	USD 1,680.00	BP-01832-1g	In stock	Get quote
5 g	Inquire	BP-01832-5g	Inquire	Inquire

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Description

GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4. GSK2018682 is used in the research of multiple sclerosis.

Biological activity

In Vitro GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4.

Identifiers

SMILES: CC(C)OC1=C(Cl)C=C(C=N1)C1=NC(=NO1)C1=C2C=CN(CCCC(O)=O)C2=CC=C1
InChIKey: NFIGDBFIDKDNIG-UHFFFAOYSA-N

Specifications

MW (average): 440.8800
Formula: C₂₂H₂₁ClN₄O₄
CAS No.: 1034688-30-6
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 40℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Xu J, et al. Safety, pharmacokinetics, pharmacodynamics, and bioavailability of GSK2018682, a sphingosine-1-phosphate receptor modulator, in healthy volunteers. Clin Pharmacol Drug Dev. 2014 May;3(3):170-8.

Same target

Search LPL Receptor

Same research area

Search Inflammation/Immunology