TNG908 free base · Synonyms: TNG-908 · TNG 908

TNG908 is a MTAP-cooperative PRMT5 inhibitor.

For research use only. Not for human or veterinary use.

Target Histone Methyltransferase

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

TNG908 structure

CAS No.: 2760481-53-4

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 585.00	BP-02048-100mg	In stock	Get quote
250 mg	USD 1,085.00	BP-02048-250mg	In stock	Get quote
500 mg	USD 1,585.00	BP-02048-500mg	In stock	Get quote
1 g	Inquire	BP-02048-1g	In stock	Inquire

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Description

TNG908 is a MTAP-cooperative PRMT5 inhibitor that can pass through the blood-brain barrier. TNG908 can be used in cancer research.

Biological activity

In Vitro TNG908 (0-10 μM, 24 h) is 15 times more selective for MTAPnull cell lines than MTAPWT cell lines, and the stability of human liver microsomes is C< sub>lint=14 μL/min/mg. In Vivo TNG908 (1-120 mg/kg twice daily for 21 days, p.o. or i.v.) A promotes tumor regression in LU99 NSCLC cell line-derived xenograft mouse model.

Identifiers

SMILES: CC1=CC(NC(C(N2[C@@H](C3=CC=C(SC=N4)C4=C3)CC[C@@H](C2)C)=O)=O)=CN=C1N
InChIKey: NXXBDYHMHHINFC-YVEFUNNKSA-N

Specifications

MW (average): 409.5050
Formula: C₂₁H₂₃N₅O₂S
CAS No.: 2760481-53-4
Physical state: Solid
Color: White to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO, >50 mg/mL

Documents

References

[1]. K. Briggs, et al. TNG908 is a brain-penetrant, MTA-cooperative PRMT5 inhibitor for the treatment of MTAP-deleted cancer.MOLECULAR TARGETED AGENTS 2| VOLUME 174, SUPPLEMENT 1, S84, OCTOBER 2022.

Same target

Search Histone Methyltransferase

Same research area

Search Cancer