ABBV-CLS-484 free base · Synonyms: Osunprotafib

ABBV-CLS-484 is a potent PTPN1 or PTPN2 inhibitor.

For research use only. Not for human or veterinary use.

Target Phosphatase STATJ AK

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

ABBV-CLS-484 structure

CAS No.: 2489404-97-7

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
5 mg	USD 798.00	BP-02361-5mg	In stock	Get quote
10 mg	USD 1,298.00	BP-02361-10mg	In stock	Get quote
25 mg	USD 2,398.00	BP-02361-25mg	In stock	Get quote
50 mg	Inquire	BP-02361-50mg	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

ABBV-CLS-484 is a potent PTPN1 or PTPN2 inhibitor with a sub-nanomolar activity.

Biological activity

ABBV-CLS-484 (Osunprotafib) is an first-in-class, orally active, potent PTPN2/PTPN1 active site inhibitor with an EC50 of 0.176 μM that enhances the sensitivity of tumor cells to IFNγ and promotes T cell activation and function.

Identifiers

SMILES: FC1=C(C[C@@H](CC2)NCCC(C)C)C2=CC(O)=C1N3CC(NS3(=O)=O)=O
InChIKey: DVFCRTGTEXUFIN-GFCCVEGCSA-N

Specifications

MW (average): 385.4540
Formula: C₁₇H₂₄FN₃O₄S
CAS No.: 2489404-97-7
Physical state: Solid
Color: White to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years, 4°C 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO 58.33 mg/mL

Documents

References

[1]. Philip R. Kym, et al. Protein tyrosine phosphatase inhibitors and methods of use thereof. WO2022056281A1.

[2]. Arvin Iracheta-Vellve, et al. Targeting the immune checkpoint PTPN2 with ABBV-CLS-484 inflames the tumor microenvironment and unleashes potent CD8+ T cell immunity. Cancer Res (2022) 82 (12_Supplement): 606.

[3]. Christina K, et al. ABBV-CLS-484: An active site PTPN2/N1 inhibitor that augments the immune response and sensitizes tumors to immune-mediated killing. Cancer Res (2022) 82 (12_Supplement): ND06.

[4]. Baumgartner CK, et al. The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity. Nature. 2023 Oct;622(7984):850-862.

Same target

Search Phosphatase

Same research area

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