Cipepofol free base

Cipepofol, a novel 2,6-disubstituted phenol derivative, is a positive allosteric modulator and direct agonist of the GABAA receptor.

For research use only. Not for human or veterinary use.

Target GABA Receptor Sirtuin Keap1-Nrf2 Apoptosis

Research area Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

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Data Sheet SDS COA

Cipepofol structure

CAS No.: 1637741-58-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 495.00	BP-01915-50mg	In stock	Get quote
100 mg	USD 792.00	BP-01915-100mg	In stock	Get quote
250 mg	USD 1,190.00	BP-01915-250mg	In stock	Get quote
500 mg	Inquire	BP-01915-500mg	In stock	Inquire
1 g	Inquire	BP-01915-1g	Inquire	Inquire

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Description

Cipepofol (Ciprofol), a novel 2,6-disubstituted phenol derivative, is a positive allosteric modulator and direct agonist of the GABAA receptor. Cipepofol can cause the central nerve inhibition and promote sleep based on the structural modification of Propofol. Cipepofol can activate the sirtuin1 (Sirt1)/Nrf2 pathway. Cipepofol protects the heart against Isoproterenol-induced myocardial infarction by reducing cardiac oxidative stress, inflammatory response and cardiomyocyte apoptosis

Biological activity

In Vitro Cipepofol (Ciprofol) can trigger chloride influx by competitive binding to butylbicyclophosphorothionate and t-butylbicycloorthobenzoate targets in the chloride channels of GABAA receptors. The influx of chloride can cause hyperpolarization of nerve cell membranes by increasing the intracellular chloride concentration and further activating GABAergic neurons to achieve central nerve inhibition. Cipepofol (5 μM before ISO insult for 6 h) blunts the contents of CK-MB, LDH and cTnT were increased in ISO-treated H9c2 cells. Cipepofol attenuates ISO-induced cardiomyocyte apoptosis in vitro. In Vivo Cipepofol (Ciprofol; 100 μL; implanted into the abdomen of mice 1 h before ISO) suppresses ISO-induced myocardial damage, cardiac dysfunction, and inflammation and cardiomyocyte apoptosis.

Identifiers

SMILES: C[C@H](C1CC1)C2=CC=CC(=C2O)C(C)C
InChIKey: BMEARIQHWSVDBS-SNVBAGLBSA-N

Specifications

MW (average): 204.3080
Formula: C₁₄H₂₀O
CAS No.: 1637741-58-2
Physical state: Liquid
Color: Colorless to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Pure form -20°C, 3 years , 4°C, 2 years; In solvent -20°C, 1 month.

Solubility

Soluble in DMSO : 100 mg/mL

Documents

References

[1]. Ming Lu, et al. Ciprofol: A Novel Alternative to Propofol in Clinical Intravenous Anesthesia? Biomed Res Int. 2023 Jan 19:2023:7443226.

[2]. Yunzhao Yang, et al. Ciprofol attenuates the isoproterenol-induced oxidative damage, inflammatory response and cardiomyocyte apoptosis. Front Pharmacol. 2022 Nov 22:13:1037151.

Same target

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Same research area

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