Runcaciguat free base · Synonyms: BAY 1101042
Runcaciguat is an orally active stimulator of soluble guanylate cyclase, and is used in the research of cardiovascular and renal diseases combined…
For research use only. Not for human or veterinary use.
Runcaciguat structure
CAS No.: 1402936-61-1
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 50 mg | USD 400.00 | BP-01884-50mg | In stock | Get quote |
| 100 mg | USD 620.00 | BP-01884-100mg | In stock | Get quote |
| 250 mg | USD 1,020.00 | BP-01884-250mg | In stock | Get quote |
| 500 mg | USD 1,520.00 | BP-01884-500mg | In stock | Get quote |
| 1 g | USD 2,450.00 | BP-01884-1g | In stock | Get quote |
| 2 g | Inquire | BP-01884-2g | Inquire | Inquire |
Need another size or custom synthesis? Request a quote.
Description
Runcaciguat is an orally active stimulator of soluble guanylate cyclase, and is used in the research of cardiovascular and renal diseases combined with selective partial adenosine A1 receptor agonists.
Biological activity
In Vitro Runcaciguat (100 pM-10 μM; 10 min) activates wild-type soluble guanylate cyclase (sGC, EC50=789 nM) in HEK293 cells, but inactive against the β1H105A/F mutant, confirming that its activation is dependent on the histidine 105 residue of the β1 subunit. In Vivo Runcaciguat (1-10 mg/kg; oral gavage or mixed feed; 1-2 times a day; 2-12 weeks) significantly reduces proteinuria, improves renal function markers (such as Cyst-C, KIM-1), alleviates renal pathological damage (such as glomerular sclerosis, tubular degeneration) in chronic kidney disease (CKD) models such as ANG-SD rats, RenTG rats, ZDF rats and ZSF1 rats, and improves the survival rate of RenTG rats.
Identifiers
- SMILES
-
O=C(NC1=CC([C@H](C2CC2)CC(O)=O)=CC=C1Cl)[C@@](C3=CC=C(Cl)C=C3)([H])[C@@H](C)C(F)(F)F - InChIKey
-
NCRMKIWHFXSBGZ-CNBXIYLPSA-N
Specifications
- MW (average)
- 488.3270
- Formula
- C23H22Cl2F3NO3
- CAS No.
- 1402936-61-1
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO 125 mg/mL