Gemigliptin tartrate free base · Synonyms: LC15-0444 tartrate

Gemigliptin tartrate is a highly selective, reversible and competitive dipeptidyl peptidase-4 inhibitor.

For research use only. Not for human or veterinary use.

Target Dipeptidyl Peptidase

Research area Metabolic Disease

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Data Sheet SDS COA

Gemigliptin tartrate structure

CAS No.: 1374639-74-3

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Pack sizes & pricing

Size	Price	SKU	Stock
1 g	USD 725.00	BP-00062-1g	In stock	Get quote
5 g	USD 2,175.00	BP-00062-5g	In stock	Get quote

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Description

Gemigliptin tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC50 of 10.3 nM for human recombinant DPP-4.

Biological activity

In Vitro Gemigliptin tartrate dose-dependently inhibits the formation of AGE-BSA with IC50 of 11.69 mM[1]. Gemigliptin tartrate dose-dependently suppresses the cross-linking of preformed AGE-BSA with rat tail tendon collagen with an IC50 of 1.39 mM[1]. Gemigliptin tartrate is a competitive DPP-4 inhibitor with a Ki of 7.25 nM[2]. In Vivo Gemigliptin tartrate (100 mg/kg; i.g.; daily; for 12 weeks) inhibits AGEs formation and AGE cross-links in vivo[1]. Gemigliptin tartrate dose-dependently inhibits plasma DPP-4 activity in rats, dogs, and monkeys[2].

Specifications

MW (average): 639.4498
Formula: C₂₂H₂₅F₈N₅O₈
CAS No.: 1374639-74-3
Physical state: Solid
Color: white to orange
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4℃, sealed storage, away from moisture, 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Jung E, et al. Gemigliptin, a novel dipeptidyl peptidase-4 inhibitor, exhibits potent anti-glycation properties in vitro and in vivo. Eur J Pharmacol. 2014 Dec 5;744:98-102.

[2]. Kim SH, et al. Pharmacological profiles of gemigliptin (LC15-0444), a novel dipeptidyl peptidase-4 inhibitor, in vitro and in vivo. Eur J Pharmacol. 2016 Oct 5;788:54-64.

Same target

Search Dipeptidyl Peptidase

Same research area

Search Metabolic Disease