Enbezotinib free base · Synonyms: TPX-0046

Enbezotinib, an inhibitor of RET, can inhibit the RET autophosphorylation.

For research use only. Not for human or veterinary use.

Target RET

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

Enbezotinib structure

CAS No.: 2359649-81-1

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 450.00	BP-02002-50mg	In stock	Get quote
100 mg	USD 700.00	BP-02002-100mg	In stock	Get quote
250 mg	USD 1,350.00	BP-02002-250mg	In stock	Get quote
500 mg	USD 2,000.00	BP-02002-500mg	In stock	Get quote
1 g	USD 3,100.00	BP-02002-1g	In stock	Get quote

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Description

Enbezotinib, an inhibitor of RET, can inhibit the RET autophosphorylation. Enbezotinib can be used for the research of cancer.

Biological activity

In Vitro Enbezotinib (compound 5) (0.3-300 nM) inhibits p-RET (y905) in RET-driven cells. In Vivo Enbezotinib (compound 5) (2-5 mg/kg; twice daily for 27 days) decreases tumor size in mice.

Identifiers

SMILES: FC1=CN=C(O[C@@H](C)CNC2=O)C(CN3C4=NC5=C2C=NN5C=C4O[C@@H]6[C@H]3CCC6)=C1
InChIKey: BYYQDEOVMILBQT-XZJROXQQSA-N

Specifications

MW (average): 424.4282
Formula: C₂₁H₂₁FN₆O₃
CAS No.: 2359649-81-1
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO 100 mg/mL

Documents

References

[1]. ROGERS EW, et, al. Macrocyclic compounds for treating disease. WO2019126121A1.

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