Corin free base

Corin is a dual inhibitor of histone lysine specific demethylase.

For research use only. Not for human or veterinary use.

Target Histone Demethylase HDAC

Research area Cancer

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Data Sheet SDS COA

Corin structure

CAS No.: 1808113-09-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
25 mg	USD 585.00	BP-02518-25mg	In stock	Get quote
50 mg	USD 990.00	BP-02518-50mg	In stock	Get quote
100 mg	USD 1,650.00	BP-02518-100mg	In stock	Get quote
1 g	Inquire	BP-02518-1g	In stock	Inquire

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Description

Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1.

Biological activity

In Vitro Corin is able to inhibit the deacetylation of semisynthetic, reconstituted nucleosomes by the CoREST ternary complex. Corin shows irreversible inhibition of HDAC1 activity. In Comparison to MS-275, corin appears to more potently (Corin EC50 95 nM vs. MS-275 EC50 420 nM) and efficaciously induce cellular H3K9 acetylation. Interestingly, Corin (1 μM) is non-toxic to primary human melanocytes in contrast to MS-275 (1 μM)

Identifiers

SMILES: O=C(NC1=CC=C([C@H]2[C@H](N)C2)C=C1)CCCC3=CC=C(C(NC4=CC=CC=C4N)=O)C=C3
InChIKey: TYTLARZOLKJSJU-JTHBVZDNSA-N

Specifications

MW (average): 428.5261
Formula: C₂₆H₂₈N₄O₂
CAS No.: 1808113-09-8
Physical state: Solid
Color: Off-white to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, stored under nitrogen

Solubility

Soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1].Kalin JH, et al. Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors. Nat Commun. 2018 Jan 4;9(1):53.

Same target

Search Histone Demethylase

Same research area

Search Cancer