GSK690 hydrochloride salt form · hydrochloride · Parent GSK690 hydrochloride
GSK 690 is a reversible inhibitor of lysine specific demethylase 1.
For research use only. Not for human or veterinary use.
GSK690 hydrochloride structure
CAS No.: 2436760-79-9
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 50 mg | USD 495.00 | BP-02163A-50mg | In stock | Get quote |
| 100 mg | USD 780.00 | BP-02163A-100mg | In stock | Get quote |
| 250 mg | USD 1,540.00 | BP-02163A-250mg | In stock | Get quote |
| 500 mg | USD 2,500.00 | BP-02163A-500mg | In stock | Get quote |
| 1 g | USD 3,980.00 | BP-02163A-1g | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
GSK 690 (Hydrochloride) is a reversible inhibitor of lysine specific demethylase 1 (LSD1), with a Kd value of 9 nM and a biochemical IC50 of 37 nM.
Biological activity
In Vitro GSK690 (1-10 μM) acts together with JNJ-26481585 to induce cell death in all four tested RMS cells lines (RD, RH30, RMS13, and TE381.T cells). GSK690/JNJ-26481585 cotreatment alters the balance between pro- and antiapoptotic proteins with 1 μM GSK690 for RD cells and 10 μM GSK690 for RH30 cells. GSK690/JNJ-26481585 cotreatment induces caspase-dependent cell death with 1 μM GSK690 for RD cells and 10 μM GSK690 for RH30 cells. The addition of GSK690 further enhances the JNJ-26481585-stimulated G2/M arrest .
Identifiers
- SMILES
-
N#CC1=CC=C(C2=CC(OC[C@H]3CNCC3)=CN=C2C4=CC=C(C)C=C4)C=C1.Cl - InChIKey
-
DBTSJYXXWZFXNJ-FSRHSHDFSA-N
Specifications
- MW (average)
- 405.9200
- Formula
- C24H24ClN3O
- CAS No.
- 2436760-79-9
- Physical state
- Solid
- Color
- light yellow to yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder 4℃, sealed storage, away from moisture 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO : 125 mg/mL