GSK2982772 free base · Synonyms: GSK-2982772 · GSK 2982772
GSK2982772 is a potent, orally active and ATP competitive RIP1 kinase inhibitor.
For research use only. Not for human or veterinary use.
GSK2982772 structure
CAS No.: 1622848-92-3
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 500 mg | USD 850.00 | BP-02513-500mg | In stock | Get quote |
| 1 g | USD 1,350.00 | BP-02513-1g | In stock | Get quote |
| 2 g | USD 2,298.00 | BP-02513-2g | In stock | Get quote |
| 5 g | Inquire | BP-02513-5g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
GSK2982772 is a potent, orally active and ATP competitive RIP1 kinase inhibitor with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively .
Biological activity
GSK2982772 is a potent inhibitor of selective receptor interaction protein kinase 1 (RIPK1), with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively. GSK2982772 binds effectively to RIP1, has sensitive kinase specificity, and has excellent activity in blocking many TNF-dependent cellular responses. RIP1 is an important upstream kinase that has been shown to regulate inflammation through specific functions of scaffold and kinase. In vivo, GSK2982772 showed good free fractions in the blood of rats (4.2%), dogs (11%), cynomolgus monkeys (11%), and humans (7.4%).
Identifiers
- SMILES
-
CN1C2=CC=CC=C2OC[C@H](NC(=O)C2=NC(CC3=CC=CC=C3)=NN2)C1=O - InChIKey
-
LYPAFUINURXJSG-AWEZNQCLSA-N
Specifications
- MW (average)
- 377.3966
- Formula
- C20H19N5O3
- CAS No.
- 1622848-92-3
- Physical state
- Solid
- Color
- White to yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 year
Solubility
Soluble in DMSO; H2O