Nec-1s free base · Synonyms: Necrostatin 2 racemate

Necrostatin 2 is a potent necroptosis inhibitor.

For research use only. Not for human or veterinary use.

Target RIP kinase

Research area Cancer

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Data Sheet SDS COA

Nec-1s structure

CAS No.: 852391-15-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 485.00	BP-02348-100mg	In stock	Get quote
250 mg	USD 685.00	BP-02348-250mg	In stock	Get quote
1 g	USD 1,285.00	BP-02348-1g	In stock	Get quote
5 g	Inquire	BP-02348-5g	In stock	Inquire

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Description

Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.

Biological activity

Necrostatin-2 racemate (also known as 7-Cl-O-Nec-1 and Nec-1s) is a potent and specific receptor-interacting protein kinase 1 (RIPK1) inhibitor lacking the IDO-targeting effect, with >1000-fold more selective for RIPK1 than for any other kinase out of 485 human kinases. In vivo, Nec-1s is effective in reducing brain injuries. It is a superior inhibitor suitable for use in vivo lacking a paradoxical sensitizing effect in TNF-induced lethality. Nec-1s possesses several advantageous pharmacokinetic and pharmacodynamic characteristics in comparison to Nec-1. Safety profile of Nec-1s is also superior to that of Nec-1 for reduced in vivo and in vitro toxicity.

Identifiers

SMILES: CN1C(=O)NC(CC2=CNC3=C(Cl)C=CC=C23)C1=O
InChIKey: WIKGAEMMNQTUGL-UHFFFAOYSA-N

Specifications

MW (average): 277.7060
Formula: C₁₃H₁₂ClN₃O₂
CAS No.: 852391-15-2
Physical state: Solid
Color: White to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : ≥ 50 mg/mL

Documents

References

[1]. Meng, H., Wu, G., Zhao, X. et al. Discovery of a cooperative mode of inhibiting RIPK1 kinase. Cell Discov 7, 41 (2021). https://doi.org/10.1038/s41421-021-00278-x

[2]. Takahashi, N., et al. . Necrostatin-1 analogues: Critical issues on the specificity, activity and in vivo use in experimental disease models. Cell Death Dis. 3, e437 (2012).

[3]. Huang, Z., et al. Necrostatin-1 rescues mice from lethal irradiation. Biochim. Biophys. Acta 1862(4), 850-856 (2016).

Same target

Search RIP kinase

Same research area

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