Cevipabulin free base · Synonyms: TTI-237

Cevipabulin (TTI-237) is an oral, microtubule-active antitumor compound and inhibits the binding of [ 3H] vinblastine to tubulin, with an IC50 of…

For research use only. Not for human or veterinary use.

Target Microtubule/Tubulin

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

Cevipabulin structure

CAS No.: 849550-05-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 420.00	BP-02475-50mg	In stock	Get quote
250 mg	USD 840.00	BP-02475-250mg	In stock	Get quote
500 mg	USD 1,340.00	BP-02475-500mg	In stock	Get quote
1 g	USD 2,150.00	BP-02475-1g	In stock	Get quote
2 g	USD 3,440.00	BP-02475-2g	In stock	Get quote
3 g	USD 4,128.00	BP-02475-3g	In stock	Get quote
5 g	USD 5,500.00	BP-02475-5g	In stock	Get quote

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Description

Cevipabulin (TTI-237) is an oral, microtubule-active antitumor compound and inhibits the binding of [ 3H] vinblastine to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line .

Biological activity

In Vitro Cevipabulin (0-50 nM, 72 hours) shows good activity (between 18 and 40 nM IC50 values) on cell lines from ovarian, breast, prostate, and cervical tumors. Flow cytometry experiments reveal that, Cevipabulin (TTI-237) at low concentrations (20-40 nM) produces sub-G1 nuclei and, at concentrations above 50 nM, it causes a strong G2-M block. n Vivo Cevipabulin (TTI-2370)( 5, 10, 15, and 20 mg/kg, every 4 days for 4 cycles, in mice) is active by i.v. and p.o. administration against human tumor xenografts, showing dose-dependent effects, with good antitumor activity at 20 and 15 mg/kg.

Identifiers

SMILES: CNCCCOC1=CC(F)=C(C(F)=C1)C1=C(N[C@@H](C)C(F)(F)F)N2N=CN=C2N=C1Cl
InChIKey: ZUZPCOQWSYNWLU-VIFPVBQESA-N

Specifications

MW (average): 464.8200
Formula: C₁₈H₁₈ClF₅N₆O
CAS No.: 849550-05-6
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years ; In solvent -20°C, 1 month;

Solubility

Soluble in DMSO

Documents

References

[1].Beyer CF, et al. TTI-237: a novel microtubule-active compound with in vivo antitumor activity. Cancer Res. 2008 Apr 1;68(7):2292-300.

[2]. Beyer CF, et al. The microtubule-active antitumor compound TTI-237 has both paclitaxel-like and vincristine-like properties. Cancer Chemother Pharmacol. 2009 Sep;64(4):681-9.

Same target

Search Microtubule/Tubulin

Same research area

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