PF-06658607 free base · Synonyms: PF 06658607 · PF06658607

PF-06658607 is an alkynylated irreversible Brutons tyrosine kinase inhibitor.

For research use only. Not for human or veterinary use.

Target Btk

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

PF-06658607 structure

CAS No.: 1621002-24-1

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
25 mg	USD 510.00	BP-02450-25mg	In stock	Get quote
50 mg	USD 816.00	BP-02450-50mg	In stock	Get quote
100 mg	USD 1,300.00	BP-02450-100mg	In stock	Get quote
250 mg	USD 2,600.00	BP-02450-250mg	In stock	Get quote
500 mg	USD 4,180.00	BP-02450-500mg	In stock	Get quote
1 g	Inquire	BP-02450-1g	In stock	Inquire

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Description

PF-06658607 is an alkynylated irreversible Brutons tyrosine kinase (BTK) inhibitor that covalently reacts with active site cysteines in the ATP-binding pocket. PF-06658607 can be used to detect "off "-targets for covalent kinase inhibitors in cancer cells. The alkyne moiety allows for azide-based detection probe via copper-catalyzed click chemistry .

Identifiers

SMILES: C=CC(N1C[C@H](N2N=C(C3=CC=C(OC4=CC=CC(C#C)=C4)C=C3)C5=C(N)N=CN=C52)CCC1)=O
InChIKey: SFTPIUYKBLYRKF-HXUWFJFHSA-N

Specifications

MW (average): 464.5185
Formula: C₂₇H₂₄N₆O₂
CAS No.: 1621002-24-1
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month;

Solubility

Soluble in DMSO

Documents

References

[1].Lanning BR, et al. A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors. Nat Chem Biol. 2014 Sep;10(9):760-767.

Same target

Search Btk

Same research area

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