(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine free base

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual-targeting PROTAC molecule.

For research use only. Not for human or veterinary use.

Target PROTACs TGF-beta/Smad HIF/HIF Prolyl-Hydroxylase

Research area Cardiovascular Disease Inflammation/Immunology Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine structure

CAS No.: 2347517-69-3

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 580.00	BP-02401-50mg	In stock	Get quote
100 mg	USD 928.00	BP-02401-100mg	In stock	Get quote
250 mg	USD 1,850.00	BP-02401-250mg	In stock	Get quote
500 mg	USD 2,970.00	BP-02401-500mg	In stock	Get quote
1 g	USD 4,750.00	BP-02401-1g	In stock	Get quote
2 g	Inquire	BP-02401-2g	In stock	Inquire
3 g	Inquire	BP-02401-3g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual-targeting PROTAC molecule. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine not only targets the ubiquitination and degradation of Smad3, but also elevates the protein level of HIF-α, thereby exerting multi-pathway anti-fibrotic and renoprotective effects. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine can be used in a wide range of tumor studies including cancers with KRAS inhibitor resistance, covering pancreatic ductal adenocarcinoma, acute myeloid leukemia, and various soft tissue sarcomas (such as fibrosarcoma, liposarcoma, chondrosarcoma, etc.). (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine can also be applied to research related to various solid tumors and hematological malignancies, involving multiple cancer types such as colon cancer, breast cancer, ovarian cancer, non-small cell lung cancer, glioblastoma, and melanoma .

Identifiers

SMILES: O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCC(NC(C4=CN=CC=C4)C5=CC6=CC=CC=C6O5)=O)=O
InChIKey: NQNKFJCCIWJMPC-LVNYTEOHSA-N

Specifications

MW (average): 750.9060
Formula: C₄₁H₄₆N₆O₆S
CAS No.: 2347517-69-3
Physical state: Solid
Color: White to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: 4°C, sealed storage, away from moisture and light

Solubility

Soluble in DMSO : ≥ 170 mg/mL

Documents

References

[1].Pingping Hou, et al. Compositions and methods for use in kras-targeted therapies for the treatment of cancer. US20250339520A1. 2025-05-01.

Same target

Search PROTACs

Same research area

Search Cardiovascular Disease