LEE011 free base · Synonyms: Ribociclib

Ribociclib is a highly specific CDK4/6 inhibitor.

For research use only. Not for human or veterinary use.

Target CDK

Research area Neurological Disease Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

LEE011 structure

CAS No.: 1211441-98-3

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
10 g	USD 250.00	BP-02301-10g	In stock	Get quote
25 g	USD 500.00	—	In stock	Get quote
50 g	USD 800.00	—	In stock	Get quote
100 g	USD 1,280.00	—	In stock	Get quote

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Description

Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.

Biological activity

In Vitro Ribociclib (500 nM; 6 days) inhibits the growth of neuroblastoma cell lines BE2C and IMR5. In Vivo Ribociclib (200 mg/kg; p.o.; 21 days) delays tumor growth in CB17-immunodeficient BE2C or 1643 xenograft mice.

Identifiers

SMILES: CN(C)C(=O)C1=CC2=CN=C(NC3=NC=C(C=C3)N3CCNCC3)N=C2N1C1CCCC1
InChIKey: RHXHGRAEPCAFML-UHFFFAOYSA-N

Specifications

MW (average): 434.5373
Formula: C₂₃H₃₀N₈O
CAS No.: 1211441-98-3
Physical state: Solid
Color: Off-white to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10.

[2]. Rader J, et al. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma. Clin Cancer Res. 2013 Nov 15;19(22):6173-82.

Same target

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