LEE011 free base · Synonyms: Ribociclib
Ribociclib is a highly specific CDK4/6 inhibitor.
For research use only. Not for human or veterinary use.
LEE011 structure
CAS No.: 1211441-98-3
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 10 g | USD 250.00 | BP-02301-10g | In stock | Get quote |
| 25 g | USD 500.00 | — | In stock | Get quote |
| 50 g | USD 800.00 | — | In stock | Get quote |
| 100 g | USD 1,280.00 | — | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.
Biological activity
In Vitro Ribociclib (500 nM; 6 days) inhibits the growth of neuroblastoma cell lines BE2C and IMR5. In Vivo Ribociclib (200 mg/kg; p.o.; 21 days) delays tumor growth in CB17-immunodeficient BE2C or 1643 xenograft mice.
Identifiers
- SMILES
-
CN(C)C(=O)C1=CC2=CN=C(NC3=NC=C(C=C3)N3CCNCC3)N=C2N1C1CCCC1 - InChIKey
-
RHXHGRAEPCAFML-UHFFFAOYSA-N
Specifications
- MW (average)
- 434.5373
- Formula
- C23H30N8O
- CAS No.
- 1211441-98-3
- Physical state
- Solid
- Color
- Off-white to yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO
Documents
- CoA On request
- Handling Instructions