Avotaciclib free base · Synonyms: BEY1107

Avotaciclib is an orally active cyclin-dependent kinase 1 inhibitor.

For research use only. Not for human or veterinary use.

Target CDK Apoptosis

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

Avotaciclib structure

CAS No.: 1983983-41-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 725.00	BP-02287-250mg	In stock	Get quote
500 mg	USD 1,125.00	BP-02287-500mg	In stock	Get quote
1 g	USD 1,685.00	BP-02287-1g	In stock	Get quote
5 g	Inquire	BP-02287-5g	In stock	Inquire

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Description

Avotaciclib (BEY1107) is an orally active cyclin-dependent kinase 1 (CDK1) inhibitor. Avotaciclib can inhibit the proliferation and induce apoptosis of tumor cells. Avotaciclib can be used in the research of cancer such as pancreatic cancer and lung cancer.

Biological activity

Avotaciclib (0-64 μM; 48 h) can inhibit cell proliferation and promote apoptosis in radiotherapy-resistant non-small cell lung cancer cell lines, and the effect is better when combined with PV-1019

Identifiers

SMILES: OC1=CC=C(C2=NC(N)=NC=C2)N=C1C3=NC(N)=NC=C3
InChIKey: VFVAQKKPFOPZEA-UHFFFAOYSA-N

Specifications

MW (average): 281.2727
Formula: C₁₃H₁₁N₇O
CAS No.: 1983983-41-0
Physical state: Solid
Color: Light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: -20°C, protect from light, stored under nitrogen

Solubility

Soluble in DMSO : 100 mg/mL

Documents

References

[1].Seufferlein T, et, al. Phase I Trials in Pancreatic Cancer. Translational Pancreatic Cancer Research pp 219-232.

[2].Zhang L, et al. Suppression of cyclin-dependent kinase 1 synergizes with checkpoint kinase 2 inhibitor to promote death of non-small cell lung cancer cells with radiotherapeutic resistance. Journal of Radiation Research and Applied Sciences, 2024, 17(2): 100900.

Same target

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Same research area

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