SGR-1505 free base · Synonyms: Zilemaltib

SGR-1505 is an orally active MALT1 allosteric inhibitor.

For research use only. Not for human or veterinary use.

Target MALT1 Apoptosis

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

SGR-1505 structure

CAS No.: 2661481-41-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 1,650.00	BP-02118-100mg	In stock	Get quote
250 mg	USD 2,950.00	BP-02118-250mg	Inquire	Get quote
500 mg	USD 4,450.00	BP-02118-500mg	Inquire	Get quote
1 g	Inquire	BP-02118-1g	Inquire	Inquire

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Description

SGR-1505 is an orally active MALT1 allosteric inhibitor. SGR-1505 can be used for research of B-cell lymphomas.

Biological activity

SGR-1505 is an orally active MALT1 allosteric inhibitor. SGR-1505 inhibits MALT1 enzymatic activity and shows anti-proliferative activity in BTK inhibitor (BTKi)-sensitive and BTKi-resistant activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cell lines. SGR-1505 can be used for research of B-cell lymphomas.

Identifiers

SMILES: FC(F)([C@]1(C2=C(C=NC3=CC(F)=NN32)N(C1)C(NC4=CN=C(N5N=CC=N5)C(Cl)=C4)=O)C)F
InChIKey: DEMHKALZEXJNJH-QGZVFWFLSA-N

Specifications

MW (average): 481.7940
Formula: C₁₈H₁₂ClF₄N₉O
CAS No.: 2661481-41-8
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO : 100 mg/mL

Documents

References

[1]. Wu Yin PhD, et al. Sgr-1505 Is a Potent MALT1 Protease Inhibitor with a Potential Best-in-Class Profile. Volume 142, Supplement 1, 2 November 2023, Page 2997.

[2]. Feng S, et al., Cyclic compounds and methods of using same. WO2021134004.

[3]. Adam Olszewski MD, et al. A Phase 1, Open-Label, Multicenter, Dose-Escalation Study of Sgr-1505 As Monotherapy in Subjects with Mature B-Cell Malignancies.Blood. Volume 142, Supplement 1, 2 November 2023, Page 3102.

Same target

Search MALT1

Same research area

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