CDDO-TFEA free base · Synonyms: CDDO trifluoethyl amide | RTA 404 | TP 500

The synthetic oleanane triterpenoid CDDO (Item No.

For research use only. Not for human or veterinary use.

Target Keap1-Nrf2 Apoptosis

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

CDDO-TFEA structure

CAS No.: 932730-52-4

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
10 mg	USD 350.00	BP-02108-10mg	In stock	Get quote
25 mg	USD 635.00	BP-02108-25mg	In stock	Get quote
50 mg	USD 998.00	BP-02108-50mg	In stock	Get quote
100 mg	USD 1,680.00	BP-02108-100mg	In stock	Get quote
250 mg	Inquire	BP-02108-250mg	In stock	Inquire

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Description

The synthetic oleanane triterpenoid CDDO (Item No. 81035) is a Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. CDDO-TFEA is a trifluoroethylamide derivative of CDDO with enhanced ability to cross the blood brain barrier. It has been shown to enhance Nrf2 expression and signaling in various models of neurodegeneration, including those that simulate multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. CDDO-TFEA induces apoptosis of Ewing's sarcoma and neuroblastoma cell lines, preventing colony formation at IC50 values ranging from 85-170 nM.

Biological activity

CDDO-TFEA (RTA 404; TP-500) is a trifluoroacetamide derivative of CDDO with enhanced ability to cross the blood-brain barrier. CDDO is an Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. CDDO-TFEA can enhance Nrf2 expression and signaling in various neurodegenerative disease models. CDDO-TFEA induces apoptosis and blocks colony formation in Ewing's sarcoma and neuroblastoma cell lines with IC50 values ranging of 85-170 nM.

Identifiers

SMILES: FC(F)(F)CNC([C@]12[C@](CC(C)(CC2)C)([H])[C@]3([H])[C@@](CC1)([C@]4(C([C@@]5([C@@](C(C)(C(C(C#N)=C5)=O)C)([H])CC4)C)=CC3=O)C)C)=O
InChIKey: UBRASLQCAYTTEB-KPOXMGGZSA-N

Specifications

MW (average): 572.7013
Formula: C₃₃H₄₃F₃N₂O₃
CAS No.: 932730-52-4
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO

In vitro: DMSO : 8.33 mg/mL

Documents

References

[1]. Stack, et al. Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington’s disease. Free Radic. Biol. Med. 49(2), 147-158 (2010).

Same target

Search Keap1-Nrf2

Same research area

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