NSD2-IN-1 free base · Synonyms: CPDP802331

NSD2-IN-1 is a potent and high selective NSD2-PWWP1 inhibitor.

For research use only. Not for human or veterinary use.

Target Apoptosis

Research area Cancer

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Data Sheet SDS COA

NSD2-IN-1 structure

CAS No.: 2797183-37-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 580.00	BP-02055-50mg	In stock	Get quote
100 mg	USD 880.00	BP-02055-100mg	In stock	Get quote
250 mg	USD 1,280.00	BP-02055-250mg	In stock	Get quote
500 mg	USD 1,780.00	BP-02055-500mg	In stock	Get quote
1 g	Inquire	BP-02055-1g	In stock	Inquire

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Description

NSD2-IN-1 (compound 38) is a potent and high selective NSD2-PWWP1 (nuclear receptor-binding SET domain 2-PWWP1) inhibitor, with an IC50 of 0.11 μM. NSD2-IN-1 can bind to NSD2-PWWP1 and then affect the expression of genes regulated by NSD2. NSD2-IN-1 induces apoptosis and cell cycle arrest.

Biological activity

In Vitro NSD2-IN-1 inhibits cell proliferation in MV4:11, RS4:11, KMS11, and MM1S cells, with IC50 values of 2.23, 6.30, 8.43, and 10.95 μM, respectively[1].

Identifiers

SMILES: CN1C=NC(C2=C(C=C(C=C2C)CN3CCC(CC3)N)C)=C1C4=CC=C(C5=C4C=CC=C5)C#N
InChIKey: YELBNEVEPNGEGQ-UHFFFAOYSA-N

Specifications

MW (average): 449.5899
Formula: C₂₉H₃₁N₅
CAS No.: 2797183-37-8
Physical state: Solid
Color: Off-white to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month.

Solubility

Soluble in DMSO : 50 mg/mL

Documents

References

[1]. Li N, et al. Structure-Based Discovery of a Series of NSD2-PWWP1 Inhibitors. J Med Chem. 2022 Jun 15.

Same target

Search Apoptosis

Same research area

Search Cancer