Nesuparib free base
Nesuparib is the orally active inhibitor.
For research use only. Not for human or veterinary use.
Nesuparib structure
CAS No.: 2055357-64-5
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 50 mg | USD 480.00 | BP-02155-50mg | In stock | Get quote |
| 100 mg | USD 750.00 | BP-02155-100mg | In stock | Get quote |
| 250 mg | USD 1,450.00 | BP-02155-250mg | In stock | Get quote |
| 500 mg | USD 2,280.00 | BP-02155-500mg | In stock | Get quote |
| 1 g | USD 3,600.00 | BP-02155-1g | In stock | Get quote |
| 2 g | Inquire | BP-02155-2g | In stock | Inquire |
Description
Nesuparib (JPI-547) is the orally active inhibitor for PARP 1/2 and Tankyrase 1/2 that inhibits tankyrases 1, tankyrases 2, and PARP 1 with IC50s of 5, 1 and 2 nM, respectively. Nesuparib exhibits antitumor activity and can be used in research of advanced solid tumor.
Biological activity
In Vitro Nesuparib inhibits the activities of tankyrases, stabilizes AXIN protein, affects its downstream signaling pathways (WNT/β-catenin and Hippo signaling pathway), exhibiting antitumor effect. In Vivo Nesuparib exhibits antitumor activity against Olaparib (HY-10162)-resistant breast and ovary cancer in mouse BT474 or SNU251 xenograft models.
Identifiers
- SMILES
-
N#CC1=CN=C(N2CCN(CC2)CC3=CC(NC(C4=C5NCCC4)=O)=C5C=C3)C=C1 - InChIKey
-
GRPXLKXGJAGYSD-UHFFFAOYSA-N
Specifications
- MW (average)
- 400.4763
- Formula
- C23H24N6O
- CAS No.
- 2055357-64-5
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20°C 3 years, 4°C 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO 60 mg/mL