AZD-9898 free base · Synonyms: AZD 9898 · AZD9898

AZD9898 is an orally active leukotriene-C4 synthetase inhibitor.

For research use only. Not for human or veterinary use.

Target Glutathione S-transferase

Research area Inflammation/Immunology

Purity >98% Stock Inquire

Data Sheet SDS COA

AZD-9898 structure

CAS No.: 2042347-69-1

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
10 mg	USD 380.00	BP-01963-10mg	In stock	Get quote
25 mg	USD 608.00	BP-01963-25mg	In stock	Get quote
50 mg	USD 858.00	BP-01963-50mg	In stock	Get quote
100 mg	USD 1,208.00	BP-01963-100mg	In stock	Get quote
250 mg	USD 1,968.00	BP-01963-250mg	In stock	Get quote
500 mg	USD 2,758.00	BP-01963-500mg	In stock	Get quote
1 g	Inquire	BP-01963-1g	In stock	Inquire

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Description

AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma.

Biological activity

AZD9898 with the single dose of 100 mg/kg is well tolerated and no safety concerns are raised

Identifiers

SMILES: O=C(C1=NC=C(N(C2=C(C=C(C(Cl)=C2)F)F)CC(C)(F)C)N=C1OC)[C@@H]3[C@H](C3)C(O)=O
InChIKey: RVMWIVNHZMXEHS-UWVGGRQHSA-N

Specifications

MW (average): 457.8310
Formula: C₂₀H₁₉ClF₃N₃O₄
CAS No.: 2042347-69-1
Physical state: Solid
Color: light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO : ≥ 250 mg/mL

Documents

References

[1]. Munck Af Rosenschöld M, et al. Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for

Same research area

Search Inflammation/Immunology