NCATS-SM1441 free base

NCATS-SM1441 is a lactate dehydrogenase inhibitor.

For research use only. Not for human or veterinary use.

Target Lactate Dehydrogenase

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

NCATS-SM1441 structure

CAS No.: 1964517-04-1

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
5 mg	USD 560.00	BP-01955-5mg	In stock	Get quote
10 mg	USD 930.00	BP-01955-10mg	In stock	Get quote
25 mg	USD 1,860.00	BP-01955-25mg	In stock	Get quote
50 mg	USD 2,960.00	BP-01955-50mg	In stock	Get quote
100 mg	USD 4,800.00	BP-01955-100mg	In stock	Get quote
500 mg	Inquire	BP-01955-500mg	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

NCATS-SM1441 (compound 52) is a lactate dehydrogenase (LDH) inhibitor (IC50=40 nM). By inhibiting the activity of LDH, NCATS-SM1441 is able to reduce the production of lactic acid in cancer cells, helping to slow or stop the proliferation of cancer cells. NCATS-SM1441 can be used to study cancer metabolism .

Identifiers

SMILES: O=C(C1=CSC(N2N=C(C3=CC=CC(C#CC4=CC=C(C)S4)=C3)C(CC5=CC=C(S(=O)(N)=O)C(F)=C5)=C2CC6CC6)=N1)O
InChIKey: LZIKVHXLVMNROK-UHFFFAOYSA-N

Specifications

MW (average): 632.7480
Formula: C₃₁H₂₅FN₄O₄S₃
CAS No.: 1964517-04-1
Physical state: Solid
Color: White to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20 ℃, 3 years; 4℃ 2 year; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO 100 mg/mL

Documents

References

[1]. Rai G, et al. Pyrazole-based lactate dehydrogenase inhibitors with optimized cell activity and pharmacokinetic properties[J]. Journal of medicinal chemistry, 2020, 63(19): 10984-11011.

Same research area

Search Cancer