(S)-GNE-140 free base

(S)-GNE-140 (Compound 30-S) is the S-enantiomer of GNE-140 .

For research use only. Not for human or veterinary use.

Target Lactate Dehydrogenase

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

(S)-GNE-140 structure

CAS No.: 2003234-64-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 600.00	BP-02410-50mg	In stock	Get quote
100 mg	USD 960.00	BP-02410-100mg	In stock	Get quote
250 mg	USD 1,920.00	BP-02410-250mg	In stock	Get quote
500 mg	USD 3,072.00	BP-02410-500mg	In stock	Get quote
1 g	USD 4,915.00	BP-02410-1g	In stock	Get quote
2 g	Inquire	BP-02410-2g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

(S)-GNE-140 (Compound 30-S) is the S-enantiomer of GNE-140 . (S)-GNE-140 is an effective lactate dehydrogenase (LDH) inhibitor, with IC50 values of 55 nM for LDHA and 140 nM for LDHB. (S)-GNE-140 can be used in cancer research .

Identifiers

SMILES: O=C1N[C@](C2=CSC=C2)(C3=CC=C(N4CCOCC4)C=C3)CC(O)=C1SC5=CC=CC=C5Cl
InChIKey: SUFXXEIVBZJOAP-VWLOTQADSA-N

Specifications

MW (average): 499.0450
Formula: C₂₅H₂₃ClN₂O₃S₂
CAS No.: 2003234-64-6
Physical state: Solid
Color: Off-white to gray
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO : ≥ 14.29 mg/mL

Documents

References

[1].Purkey HE, et al. Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. ACS Med Chem Lett. 2016 Aug 26;7(10):896-901.

Same target

Search Lactate Dehydrogenase

Same research area

Search Cancer