SP-420 free base · Synonyms: SP-420

Petadeferitrin (SP-420) is a tridentate iron chelator belonging to the class of iron chelators, with orally activity.

For research use only. Not for human or veterinary use.

Target Ferroptosis

Research area Metabolic Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

SP-420 structure

CAS No.: 911714-45-9

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 450.00	BP-02466-100mg	In stock	Get quote
250 mg	USD 900.00	BP-02466-250mg	In stock	Get quote
500 mg	USD 1,440.00	BP-02466-500mg	In stock	Get quote
1 g	USD 2,300.00	BP-02466-1g	In stock	Get quote
2 g	USD 3,680.00	BP-02466-2g	In stock	Get quote
3 g	USD 4,420.00	BP-02466-3g	In stock	Get quote
5 g	USD 5,890.00	BP-02466-5g	In stock	Get quote

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Description

Petadeferitrin (SP-420) is a tridentate iron chelator belonging to the class of iron chelators, with orally activity. Petadeferitrin can be used in research related to β-thalassemia .

Biological activity

In Vitro Petadeferitrin is a derivative of Desferrithiocin but has higher iron clearance efficiency compared to Desferrithiocin with an ICE (Iron Clearance Efficiency) value of 26.7. In Vivo Petadeferitrin causes renal function abnormalities, including increased serum creatinine, proteinuria, increased urine protein/creatinine ratio, and glycosuria.

Identifiers

SMILES: COCCOCCOC1=CC(=O)C(\C=C1)=C1/N[C@](C)(CS1)C(O)=O
InChIKey: OCBKBWRZCYZTGW-WCRPCQDQSA-N

Specifications

MW (average): 355.4060
Formula: C₁₆H₂₁NO₆S
CAS No.: 911714-45-9
Physical state: Solid
Color: Light yellow to khaki
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 year;

Solubility

Soluble in DMSO

Documents

References

[1].Bergeron RJ, et al. Substituent effects on desferrithiocin and desferrithiocin analogue iron-clearing and toxicity profiles. J Med Chem. 2012 Aug 23;55(16):7090-103.

[2]. Basu S, et al. Understanding the intricacies of iron overload associated with β-thalassemia: a comprehensive review[J]. Thalassemia Reports, 2023, 13(3): 179-194.

[3].Taher A T, et al. Safety and pharmacokinetics of the oral iron chelator SP‐420 in β‐thalassemia[J]. American Journal of Hematology, 2017, 92(12): 1356-1361.

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