BB-Cl-Amidine free base
BB-Cl-Amidine is a peptidylarginine deminase inhibitor.
For research use only. Not for human or veterinary use.
BB-Cl-Amidine structure
CAS No.: 1802637-39-3
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 100 mg | USD 485.00 | BP-01931-100mg | In stock | Get quote |
| 250 mg | USD 735.00 | BP-01931-250mg | In stock | Get quote |
| 500 mg | USD 1,135.00 | BP-01931-500mg | In stock | Get quote |
| 1 g | USD 1,835.00 | BP-01931-1g | In stock | Get quote |
| 5 g | Inquire | BP-01931-5g | Inquire | Inquire |
Need another size or custom synthesis? Request a quote.
Description
BB-Cl-Amidine is a peptidylarginine deminase (PAD) inhibitor.
Biological activity
In Vivo Treatment with BB-Cl-amidine subtly reduces splenomegaly in MRL/lpr mice, while there is a trend towards increased circulating levels of anti-NET antibodies with PAD inhibitor treatment. However, neither PAD inhibitor affected body weight or total IgG levels. Indeed, treatment with both Cl-amidine and BB-Cl-amidine significantly improves endothelium-dependent vasorelaxation. The BB-Cl-amidine group also shows a strong trend towards downregulation of IRGs. Treatment with either Cl-amidine or BB-Cl-amidine significantly improves muzzle alopecia, in many cases preventing it entirely.
Identifiers
- SMILES
-
ClCC(=N)NCCC[C@H](NC(=O)C1=CC=C(C=C1)C1=CC=CC=C1)C1=NC2=CC=CC=C2N1 - InChIKey
-
YDOAWJHYHGBQFI-QHCPKHFHSA-N
Specifications
- MW (average)
- 459.9710
- Formula
- C26H26ClN5O
- CAS No.
- 1802637-39-3
- Physical state
- Solid
- Color
- white to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO