PF-04620110 free base · Synonyms: PF 04620110 · PF04620110

PF-04620110 is a potent, selective and orally bioavailable diglyceride acyltransferase-1 inhibitor.

For research use only. Not for human or veterinary use.

Target Acyltransferase

Research area Metabolic Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

PF-04620110 structure

CAS No.: 1109276-89-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 878.00	BP-01635-250mg	In stock	Get quote
500 mg	USD 1,325.00	BP-01635-500mg	In stock	Get quote
1 g	USD 2,286.00	BP-01635-1g	In stock	Get quote
2 g	USD 3,462.00	BP-01635-2g	In stock	Get quote
3 g	Inquire	BP-01635-3g	In stock	Inquire
5 g	Inquire	BP-01635-5g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

PF-04620110 is a potent, selective and orally bioavailable diglyceride acyltransferase-1 (DGAT-1) inhibitor with an IC50 of 19 nM .

Biological activity

PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.

Identifiers

SMILES: O=C(C[C@@H]1CC[C@H](CC1)C2=CC=C(C=C2)N3CCOC4=NC=NC(N)=C4C3=O)O
InChIKey: GEVVQZHMFVFGLN-HDJSIYSDSA-N

Specifications

MW (average): 396.4397
Formula: C₂₁H₂₄N₄O₄
CAS No.: 1109276-89-2
Physical state: Solid
Color: white to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4℃, 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 12.5 mg/mL

Documents

References

[1]. Dow RL, et al. Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6122-5.

[2]. Dow RL, et al. Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1. ACS Med Chem Lett. 2011 Mar 18;2(5):407-12.

Same research area

Search Metabolic Disease