ALK/BH5-IN-3 free base · Synonyms: ALKBH5 inhibitor 2 (Cpd 20m)

ALKBH5-IN-3 is a selective, cell active ALKBH5 inhibitor.

For research use only. Not for human or veterinary use.

Target Anaplastic lymphoma kinase (ALK)

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

ALK/BH5-IN-3 structure

CAS No.: 1505579-77-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 416.00	BP-02399-100mg	In stock	Get quote
250 mg	USD 832.00	BP-02399-250mg	In stock	Get quote
500 mg	USD 1,330.00	BP-02399-500mg	In stock	Get quote
1 g	USD 2,130.00	BP-02399-1g	In stock	Get quote
2 g	USD 3,400.00	BP-02399-2g	In stock	Get quote
3 g	USD 4,090.00	BP-02399-3g	In stock	Get quote
5 g	Inquire	BP-02399-5g	In stock	Inquire

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Description

ALKBH5-IN-3 is a selective, cell active ALKBH5 inhibitor with an IC50 of 0.021 μM. ALKBH5-IN-3 stabilizes ALKBH5 in HepG2 cells, and increases m 6A level in intact cells. ALKBH5-IN-3 can be used as a versatile chemical probe to explore the biological function of ALKBH5. ALKBH5-IN-3 can be used for the research of Cancer .

Biological activity

In Vitro ALKBH5-IN-3 (Compound 20m) (0.3-10 μM; 72 h) increases m6A levels in HepG2 cells. ALKBH5-IN-3 (100 μM; 3 h) stabilizes ALKBH5 in HepG2 cells.

Identifiers

SMILES: O=C(C1=NN(C2=CC=CC(C(F)(F)F)=C2)C(O)=C1)O
InChIKey: VBTBURGKMCKOJC-UHFFFAOYSA-N

Specifications

MW (average): 272.1801
Formula: C₁₁H₇F₃N₂O₃
CAS No.: 1505579-77-0
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO : 31.25 mg/mL

Documents

References

[1].Fang Z, et al. Discovery of a potent, selective and cell active inhibitor of m6A demethylase ALKBH5. Eur J Med Chem. 2022 Aug 5;238:114446.

Same target

Search Anaplastic lymphoma kinase (ALK)

Same research area

Search Cancer