RGX-104 free base · Synonyms: Abequolixron hydrochloride

RGX-104 hydrochloride is a small-molecule LXR agonist.

For research use only. Not for human or veterinary use.

Target LXR

Research area Inflammation/Immunology Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

RGX-104 structure

CAS No.: 610318-03-1

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 485.00	BP-02516-50mg	In stock	Get quote
100 mg	USD 770.00	BP-02516-100mg	In stock	Get quote
250 mg	USD 1,350.00	BP-02516-250mg	In stock	Get quote
500 mg	USD 2,250.00	BP-02516-500mg	In stock	Get quote
1 g	Inquire	BP-02516-1g	In stock	Inquire

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Description

RGX-104 hydrochloride is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene.

Biological activity

RGX-104 hydrochloride is a small-molecule LXR (liver X receptor) agonist that modulates innate immunity via transcriptional activation of the ApoE gene. Oral administration of RGX-104 hydrochloride to animals bearing palpable tumors significantly suppresses the growth of multiple cancer types. Responses are seen across a wide spectrum of malignancies, including lung cancer, melanoma, glioblastoma, and ovarian, renal cell, triple-negative breast, and colon cancer.

Identifiers

SMILES: Cl.C[C@H](CCOC1=CC(CC(O)=O)=CC=C1)N(CC(C1=CC=CC=C1)C1=CC=CC=C1)CC1=CC=CC(=C1Cl)C(F)(F)F
InChIKey: LCMIYQOJZLRHTO-GJFSDDNBSA-N

Specifications

MW (average): 632.5400
Formula: C₃₄H₃₄Cl₂F₃NO₃
CAS No.: 610318-03-1
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4°C, protect from light

Solubility

Soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1].Tavazoie MF, et al. LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer. Cell. 2018 Feb 8;172(4):825-840.e18.

Same target

Search LXR

BP-02459 Abequolixron free base · >98%

Same research area

Search Inflammation/Immunology