RGX-104 free base · Synonyms: Abequolixron hydrochloride
RGX-104 hydrochloride is a small-molecule LXR agonist.
For research use only. Not for human or veterinary use.
RGX-104 structure
CAS No.: 610318-03-1
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 50 mg | USD 485.00 | BP-02516-50mg | In stock | Get quote |
| 100 mg | USD 770.00 | BP-02516-100mg | In stock | Get quote |
| 250 mg | USD 1,350.00 | BP-02516-250mg | In stock | Get quote |
| 500 mg | USD 2,250.00 | BP-02516-500mg | In stock | Get quote |
| 1 g | Inquire | BP-02516-1g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
RGX-104 hydrochloride is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene.
Biological activity
RGX-104 hydrochloride is a small-molecule LXR (liver X receptor) agonist that modulates innate immunity via transcriptional activation of the ApoE gene. Oral administration of RGX-104 hydrochloride to animals bearing palpable tumors significantly suppresses the growth of multiple cancer types. Responses are seen across a wide spectrum of malignancies, including lung cancer, melanoma, glioblastoma, and ovarian, renal cell, triple-negative breast, and colon cancer.
Identifiers
- SMILES
-
Cl.C[C@H](CCOC1=CC(CC(O)=O)=CC=C1)N(CC(C1=CC=CC=C1)C1=CC=CC=C1)CC1=CC=CC(=C1Cl)C(F)(F)F - InChIKey
-
LCMIYQOJZLRHTO-GJFSDDNBSA-N
Specifications
- MW (average)
- 632.5400
- Formula
- C34H34Cl2F3NO3
- CAS No.
- 610318-03-1
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder 4°C, protect from light
Solubility
Soluble in DMSO
- In vitro
- DMSO : 100 mg/mL