Abequolixron free base · Synonyms: RGX-104

RGX-104 is an orally bioavailable and potent liver-X nuclear hormone receptor agonist.

For research use only. Not for human or veterinary use.

Target LXR

Research area Inflammation/Immunology Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

Abequolixron structure

CAS No.: 610318-54-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 460.00	BP-02459-50mg	In stock	Get quote
100 mg	USD 740.00	BP-02459-100mg	In stock	Get quote
250 mg	USD 1,470.00	BP-02459-250mg	In stock	Get quote
500 mg	USD 2,360.00	BP-02459-500mg	In stock	Get quote
1 g	USD 3,770.00	BP-02459-1g	In stock	Get quote
2 g	Inquire	BP-02459-2g	In stock	Inquire

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Description

RGX-104 is an orally bioavailable and potent liver-X nuclear hormone receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene.

Biological activity

In Vivo Oral administration of RGX-104 (100 mg/kg, daily) to animals bearing palpable tumors significantly suppresses the growth of multiple cancer types. Co-administration of RGX-104 with anti-PD-1 is superior to administration of either RGX-104 or anti-PD-1 alone. Importantly, co-administration of RGX-104 with anti-PD-1 therapy is well tolerated by mice, with no overt signs of toxicity.

Identifiers

SMILES: O=C(O)CC1=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C3=CC=CC=C3)C4=CC=CC=C4)C)=C1
InChIKey: ZLJZDYOBXVOTSA-XMMPIXPASA-N

Specifications

MW (average): 596.0790
Formula: C₃₄H₃₃ClF₃NO₃
CAS No.: 610318-54-2
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4°C, protect from light; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1].Tavazoie MF, et al. LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer. Cell. 2018 Feb 8;172(4):825-840.e18.

Same target

Search LXR

BP-02516 RGX-104 free base · >98%

Same research area

Search Inflammation/Immunology