Dacinostat free base · Synonyms: LAQ824 | NVP-LAQ824

Dacinostat is a potent HDAC inhibitor.

For research use only. Not for human or veterinary use.

Target HDAC Autophagy

Research area Cancer

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Data Sheet SDS COA

Dacinostat structure

CAS No.: 404951-53-7

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
500 mg	USD 798.00	BP-02512-500mg	In stock	Get quote
1 g	USD 1,598.00	BP-02512-1g	In stock	Get quote
2 g	USD 2,898.00	BP-02512-2g	In stock	Get quote
5 g	Inquire	BP-02512-5g	In stock	Inquire

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Description

Dacinostat is a potent HDAC inhibitor, with an IC50 of 32 nM; Dacinostat also inhibits HDAC1 with an IC50 of 9 nM, and used in cancer research.

Biological activity

LAQ824 (NVP-LAQ824) is a potent novel histone deacetylase (HDAC) inhibitor with an IC50 of 0.032 μM. NVP-LAQ824 also inhibited patient MM cell growth in a dose- and time-dependent manner. NVP-LAQ824-induced apoptotic signaling includes up-regulation of p21, caspase cascade activation, and poly (adenosine diphosphate [ADP]) ribose (PARP) cleavage.

Identifiers

SMILES: OCCN(CCC1=CNC2=C1C=CC=C2)CC1=CC=C(\C=C\C(=O)NO)C=C1
InChIKey: BWDQBBCUWLSASG-MDZDMXLPSA-N

Specifications

MW (average): 379.4522
Formula: C₂₂H₂₅N₃O₃
CAS No.: 404951-53-7
Physical state: Solid
Color: Light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C 3 years; 4°C 2 years. In solvent -20°C 1 year

Solubility

Soluble in DMSO

Documents

References

[1].Atadja P, et al. Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor, NVP-LAQ824. Cancer Res. 2004 Jan 15;64(2):689-95.

[2].Cho YS, et al. Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824). J Med Chem. 2010 Apr 8;53(7):2952-63.

[3].Romanski A, et al. Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells. Cell Cycle. 2012 Sep 1;11(17):3219-26.

Same target

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Same research area

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