CH5424802 analog free base

Alectinib analog is a selective ALK inhibitor.

For research use only. Not for human or veterinary use.

Target Anaplastic lymphoma kinase (ALK)

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

CH5424802 analog structure

CAS No.: 1256577-71-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 598.00	BP-02500-250mg	In stock	Get quote
500 mg	USD 998.00	BP-02500-500mg	In stock	Get quote
1 g	USD 1,698.00	BP-02500-1g	In stock	Get quote
2 g	USD 2,998.00	BP-02500-2g	In stock	Get quote
5 g	Inquire	BP-02500-5g	In stock	Inquire

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Description

Alectinib analog (CH5424802 analog) is a selective ALK inhibitor with activity in blocking resistance gating mutations. The synthetic optimization of alectinib analog allows it to be combined with specific peptides to improve the ability to target cancer cells. Alectinib analog exhibits low micromolar IC50 values in antiproliferation and shows good cytotoxic effects. The inhibitory activity of alectinib analog is closely related to its stability and release of active ingredients. Alectinib analog demonstrated the ability to inhibit vascular septal length or width in an in vivo zebrafish model .

Identifiers

SMILES: CC1(C)C2=C(C3=C(N2)C=C(C=C3)C#N)C(=O)C2=CC=C(C=C12)N1CCC(CC1)N1CCOCC1
InChIKey: OVRQGEYZDUHJNZ-UHFFFAOYSA-N

Specifications

MW (average): 454.5634
Formula: C₂₈H₃₀N₄O₂
CAS No.: 1256577-71-5
Physical state: Solid
Color: White to off-white
Shipping: —
Storage: —

Solubility

Soluble in DMSO

Documents

References

[1]. Synthesis and Anti-Angiogenic Activity of Novel c(RGDyK) Peptide-Based JH-VII-139-1 Conjugates

Same target

Search Anaplastic lymphoma kinase (ALK)

Same research area

Search Cancer