CEP-37440 free base · Synonyms: CEP 37440 · CEP37440

CEP-37440 is a potent, orally active dual FAK/ALK inhibitor.

For research use only. Not for human or veterinary use.

Target Anaplastic lymphoma kinase (ALK) FAK

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

CEP-37440 structure

CAS No.: 1391712-60-9

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 595.00	BP-02495-100mg	In stock	Get quote
250 mg	USD 989.00	BP-02495-250mg	In stock	Get quote
500 mg	USD 1,698.00	BP-02495-500mg	In stock	Get quote
1 g	Inquire	BP-02495-1g	In stock	Inquire
2 g	Inquire	BP-02495-2g	In stock	Inquire

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Description

CEP-37440 is a potent, orally active dual FAK/ALK inhibitor with IC50 values of 2.3 nM and 3.5 nM for FAK and ALK, respectively. CEP-37440 decreases the cell proliferation by blocking the autophosphorylation kinase activity of FAK1 (Tyr 397) .

Biological activity

Preparation of fused bicyclic 2,4-diaminopyrimidine derivatives as a dual ALK and FAK inhibitor.

Identifiers

SMILES: CNC(=O)C1=CC=CC=C1NC1=NC(NC2=CC=C3C[C@H](CCCC3=C2OC)N2CCN(CCO)CC2)=NC=C1Cl
InChIKey: BCSHRERPHLTPEE-NRFANRHFSA-N

Specifications

MW (average): 580.1210
Formula: C₃₀H₃₈ClN₇O₃
CAS No.: 1391712-60-9
Physical state: Solid
Color: White to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 6 months

Solubility

Soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1].Salem I, et, al. The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells. Breast Cancer Res. 2016 Mar 24;18(1):37.

[2].Ott GR, et, al. Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK). J Med Chem. 2016 Aug 25;59(16):7478-96.

Same target

Search Anaplastic lymphoma kinase (ALK)

Same research area

Search Cancer