JQ-1 carboxylic acid free base

JQ-1 carboxylic acid, a-JQ-1 derivative, is a potent BET bromodomain inhibitor.

For research use only. Not for human or veterinary use.

Target Epigenetic Reader Domain PD-1/PD-L1 Ligands for Target Protein for PROTAC Androgen Receptor Ligands for E3 Ligase

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

JQ-1 carboxylic acid structure

CAS No.: 202592-23-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 498.00	BP-02507-250mg	In stock	Get quote
500 mg	USD 898.00	BP-02507-500mg	In stock	Get quote
1 g	USD 1,698.00	BP-02507-1g	In stock	Get quote
2 g	Inquire	BP-02507-2g	In stock	Inquire
5 g	Inquire	BP-02507-5g	In stock	Inquire

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Description

JQ-1 carboxylic acid, a (+)-JQ-1 derivative, is a potent BET bromodomain inhibitor. JQ-1 carboxylic acid can be used to synthesize PROTAC, which can target the degradation of BRD4.

Biological activity

JQ-1 carboxylic acid, a type of (+)-JQ-1 derivative, is a potent BET bromodomain inhibitor for downregulating PD-L1 expression on the surface of tumor cells. JQ-1 carboxylic acid can be used as a precursor to synthesize PROTACs, which targets BET bromodomains.

Identifiers

SMILES: CC1=NN=C2[C@H](CC(O)=O)N=C(C3=C(SC(C)=C3C)N12)C1=CC=C(Cl)C=C1
InChIKey: LJOSBOOJFIRCSO-AWEZNQCLSA-N

Specifications

MW (average): 400.8820
Formula: C₁₉H₁₇ClN₄O₂S
CAS No.: 202592-23-2
Physical state: Solid
Color: White to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C 3 years; 4°C 2 years. In solvent -20°C 1 year

Solubility

Soluble in DMSO

Documents

References

[1]. Huang Y, et, al. Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation. Bioconjug Chem. 2022 Jan 19;33(1):142-151.

[2]. Chen W, et, al. Dual drugs decorated bacteria irradiate deep hypoxic tumor and arouse strong immune responses. Biomaterials. 2022 Jul;286:121582.

Same target

Search Epigenetic Reader Domain

Same research area

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