WR99210 free base · Synonyms: WR-99210 · WR 99210

WR99210 is an orally active and low-toxicity dihydrofolate reductase inhibitor.

For research use only. Not for human or veterinary use.

Target Dihydrofolate reductase (DHFR) Parasite

Research area Infection

Purity >98% Stock Inquire

Data Sheet SDS COA

WR99210 structure

CAS No.: 47326-86-3

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
25 mg	USD 460.00	BP-02457-25mg	In stock	Get quote
50 mg	USD 740.00	BP-02457-50mg	In stock	Get quote
100 mg	USD 1,180.00	BP-02457-100mg	In stock	Get quote
250 mg	USD 2,360.00	BP-02457-250mg	In stock	Get quote
500 mg	USD 3,770.00	BP-02457-500mg	In stock	Get quote
1 g	USD 6,030.00	BP-02457-1g	In stock	Get quote

Need another size or custom synthesis? Request a quote.

Description

WR99210 is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 shows good antiparasitic activity and is effective against P. falciparum and P. falciparum strains (including Pyrimethamine< -resistant P. falciparum strains) as well as T. gondii .

Biological activity

In Vitro WR99210 (0-100 nM; 92 h) is highly effective against T. gondii tachyzoites in tissue culture. WR99210 (0-100 nM; 92 h) shows low cytotoxicity to human foreskin fibroblasts. In Vivo WR99210 (1.25 mg/kg; i.p.; single daily for 5 days) is highly effective against T. gondii tachyzoites in a mouse model.

Identifiers

SMILES: CC1(N=C(N=C(N1OCCCOC2=C(C=C(C(Cl)=C2)Cl)Cl)N)N)C
InChIKey: MJZJYWCQPMNPRM-UHFFFAOYSA-N

Specifications

MW (average): 394.6840
Formula: C₁₄H₁₈Cl₃N₅O₂
CAS No.: 47326-86-3
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ;

Solubility

Soluble in DMSO

Documents

References

[1]. Mui EJ, et al. Triazine Inhibits Toxoplasma gondii tachyzoites in vitro and in vivo. Antimicrob Agents Chemother. 2005 Aug;49(8):3463-7.

[2].Hastings MD, et al. Pyrimethamine and WR99210 exert opposing selection on dihydrofolatereductase from Plasmodium vivax. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13137-41.

[3]. Kiara SM, et al. In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation. Antimicrob Agents Chemother. 2009 Sep;53(9):3793-8.

Same target

Search Dihydrofolate reductase (DHFR)

Same research area

Search Infection