INF 4E free base
INF4E is a potent NLRP3 inflammasome inhibitor.
For research use only. Not for human or veterinary use.
INF 4E structure
CAS No.: 88039-46-7
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 50 mg | USD 480.00 | BP-02456-50mg | In stock | Get quote |
| 100 mg | USD 770.00 | BP-02456-100mg | In stock | Get quote |
| 250 mg | USD 1,540.00 | BP-02456-250mg | In stock | Get quote |
| 500 mg | USD 2,460.00 | BP-02456-500mg | In stock | Get quote |
| 1 g | USD 3,930.00 | BP-02456-1g | In stock | Get quote |
| 2 g | Inquire | BP-02456-2g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
INF4E is a potent NLRP3 inflammasome inhibitor. INF4E inhibits caspase-1 and NLRP3 ATPase activities. INF4E shows protection against the IR-induced myocardial injury and dysfunction .
Biological activity
In Vitro INF4E (compound 9) preventes both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner. In Vivo INF4E significantly reduces the in infarct size and lactate dehydrogenase release and improvement in postischemic left ventricular pressure. INF4E attenuates the formation of NLRP3 inflammasome complex was induced by myocardial IR (ischemia/reperfusion) in a time-dependent way.
Identifiers
- SMILES
-
CCOC(C(C(O)C1=C(Cl)C=CC=C1)=C)=O - InChIKey
-
BSRPDXCMAOIUOO-UHFFFAOYSA-N
Specifications
- MW (average)
- 240.6830
- Formula
- C12H13ClO3
- CAS No.
- 88039-46-7
- Physical state
- Liquid
- Color
- Colorless to light yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month;
Solubility
Soluble in DMSO