(Rac)-ErSO-DFP free base

(Rac)-ErSO-DFP is a derivative of ErSO-DFP and a selective small molecule Erα biomodulator.

For research use only. Not for human or veterinary use.

Target Estrogen Receptor/ERR

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

(Rac)-ErSO-DFP structure

CAS No.: 2768139-73-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 880.00	BP-02406-100mg	In stock	Get quote
250 mg	USD 1,760.00	BP-02406-250mg	In stock	Get quote
500 mg	USD 2,800.00	BP-02406-500mg	In stock	Get quote
1 g	USD 4,500.00	BP-02406-1g	In stock	Get quote
2 g	Inquire	BP-02406-2g	In stock	Inquire
3 g	Inquire	BP-02406-3g	In stock	Inquire

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Description

(Rac)-ErSO-DFP is a derivative of ErSO-DFP and a selective small molecule Erα biomodulator. (Rac)-ErSO-DFP againsts ERα+ breast cancer (including resistant tumors) by hyperactiving the Erα-dependent a-UPR (extracted from patent WO2022087234A1) .

Biological activity

In Vitro (Rac)-ErSO-DFP (compound 2) (0.001-1 µM; 24 h) maintains potent anticancer activity with IC50 of 35 nM in MCF-7 cells. In Vivo (Rac)-ErSO-DFP (compound 2) (5 mg/kg; i.v.; 3xq.wk.) shows a sustained activity of againsting ERα+ breast cancer at low doses.

Identifiers

SMILES: O=C1NC2=C(C=CC=C2C1(N3CCC(F)(CC3)F)C4=CC=C(C=C4)O)C(F)(F)F
InChIKey: IVIIASPFEXRZGM-UHFFFAOYSA-N

Specifications

MW (average): 412.3532
Formula: C₂₀H₁₇F₅N₂O₂
CAS No.: 2768139-73-5
Physical state: Solid
Color: White to pink
Shipping: —
Storage: —

Documents

References

[1].Hergenrother, et al. Enzyme-activating compounds and compositions. Patent WO2022087234A1.

Same target

Search Estrogen Receptor/ERR

Same research area

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