ErSO-DFP free base

ErSO-DFP is an anticipatory unfolded protein response activator.

For research use only. Not for human or veterinary use.

Target Estrogen Receptor/ERR

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

ErSO-DFP structure

CAS No.: 2768139-76-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 590.00	BP-02405-50mg	In stock	Get quote
100 mg	USD 944.00	BP-02405-100mg	In stock	Get quote
250 mg	USD 1,888.00	BP-02405-250mg	In stock	Get quote
500 mg	USD 3,020.00	BP-02405-500mg	In stock	Get quote
1 g	USD 4,830.00	BP-02405-1g	In stock	Get quote
2 g	Inquire	BP-02405-2g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

ErSO-DFP is an anticipatory unfolded protein response (a-UPR) activator. ErSO-DFP has enhanced selectivity for estrogen receptor alpha-positive (ERα+) cancer cells with a wider selectivity window than ErSO . ErSO-DFP displays antitumor activity against MCF-7 in mice. ErSO-DFP can cross the blood brain barrier .

Biological activity

In Vitro ErSO-DFP (0-100 μM, 24-72 h) exhibits cytotoxicity in ERα-positive cells, IC50s for MCF-7, T47D, TYS and TDG are 17 nM, 16 nM, 7 nM and 9 nM, respectively. In Vivo ErSO-DFP (5 mg/kg, iv, once weekly for 3 doses) exhibits antitumor activity in MCF-7 xenograft mouse models without significant toxicity.

Identifiers

SMILES: O=C1NC2=C(C=CC=C2[C@]1(N3CCC(F)(CC3)F)C4=CC=C(C=C4)O)C(F)(F)F
InChIKey: IVIIASPFEXRZGM-LJQANCHMSA-N

Specifications

MW (average): 412.3532
Formula: C₂₀H₁₇F₅N₂O₂
CAS No.: 2768139-76-8
Physical state: Solid
Color: White to pink
Shipping: —
Storage: —

Solubility

Soluble in DMSO : ≥ 100 mg/mL

Documents

References

[1].Matthew W Boudreau, et al. Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer. J Med Chem. 2022 Mar 10;65(5):3894-3912.

Same target

Search Estrogen Receptor/ERR

Same research area

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