TC ASK 10 free base

TC ASK 10 is a potent, selective and orally active apoptosis signal-regulating kinase 1 inhibitor.

For research use only. Not for human or veterinary use.

Target MAP3K Apoptosis

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

TC ASK 10 structure

CAS No.: 1005775-56-3

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 598.00	BP-02395-100mg	In stock	Get quote
250 mg	USD 998.00	BP-02395-250mg	In stock	Get quote
500 mg	USD 1,698.00	BP-02395-500mg	In stock	Get quote
1 g	USD 2,798.00	BP-02395-1g	In stock	Get quote
2 g	Inquire	BP-02395-2g	In stock	Inquire

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Description

TC ASK 10 (Compound 10) is a potent, selective and orally active apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 of 14 nM. The inhibitory activities of TC ASK 10 towards other representative panel of kinases are less than 50%, except for ASK2 (IC50 of 0.51 μM)[1].

Biological activity

In Vitro TC ASK 10 (Compound 10; 0-10 μM; 1 hour; INS-1 cells) treatment inhibits streptozotocin (STZ)-induced JNK in INS-1 pancreatic β cells from 0.3 μM. Phosphorylation of p38 is also inhibited in a dosedependent manner. In Vivo Pharmacokinetic profiles in rats are tested. TC ASK 10 (Compound 10 HCl; rat cassette doing at 0.1 mg/kg, iv and 1 mg/kg, po.) has a good oral bioavailability. The Cmax, Tmax and AUCpo,0-8h are 285.1 ng/mL, 1.67 h and 275.4 ng.h/mL, respectively for TC ASK 10.

Identifiers

SMILES: CC(C)(C)C1=CC=C(C=C1)C(=O)NC2=CN3C=C(C=CC3=N2)N4C=CN=C4.Cl.Cl
InChIKey: IKKLFEDUYFZNBO-UHFFFAOYSA-N

Specifications

MW (average): 432.3460
Formula: C₂₁H₂₃Cl₂N₅O
CAS No.: 1005775-56-3
Physical state: Solid
Color: White to pink
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4°C, sealed storage, away from moisture; In solvent -20°C, 1 month;

Solubility

soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1]. Terao Y, et al. Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7326-9.

Same target

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Same research area

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