BiochemProbe — Life Science Research Reagents

BLU-0588 free base · Synonyms: BLU 0588 · BLU0588

BLU0588 is an orally active, potent and selective PRKACA kinase inhibitor.

For research use only. Not for human or veterinary use.

Target PKA
Research area Cancer
Purity >98% Stock Inquire
Data Sheet SDS COA

BLU-0588 structure

CAS No.: 2810747-78-3

Download structure (.mol)

Pack sizes & pricing

Size Price SKU Stock
100 mg USD 530.00 BP-02057-100mg In stock Get quote
250 mg USD 902.00 BP-02057-250mg In stock Get quote
500 mg USD 1,375.00 BP-02057-500mg In stock Get quote
1 g Inquire BP-02057-1g In stock Inquire
Custom Size Bulk Inquiry

Description

BLU0588 is an orally active, potent and selective PRKACA (protein kinase cAMP-activated catalytic subunit alpha) kinase inhibitor, with an IC50 of 1 nM and dissociation constant (Kd) of 4 nM. BLU0588 can be used for fibrolamellar carcinoma (FLC) research.

Biological activity

BLU0588 is an orally active, potent and selective PRKACA (protein kinase cAMP-activated catalytic subunit alpha) kinase inhibitor, with an IC50 of 1 nM and dissociation constant (Kd) of 4 nM. BLU0588 can be used for fibrolamellar carcinoma (FLC) research.

Identifiers

SMILES
O=C(C1=CN=C(C2=C3C(NC=C3)=NC=C2)C=C1)N[C@H]4[C@H](N5CCCC5)CC6=CC=CC=C64
InChIKey
YXSWSKFLTNJZEO-DNQXCXABSA-N

Specifications

MW (average)
423.5096
Formula
C26H25N5O
CAS No.
2810747-78-3
Physical state
Solid
Color
White to yellow
Shipping
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage
Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -20°C, 1 month

Solubility

Soluble in DMSO : 83.33 mg/mL

Documents

References

[1]. Stefanie S. Schalm, et al. Evaluation of Protein Kinase cAMP-Activated Catalytic Subunit Alpha as a Therapeutic Target for Fibrolamellar Carcinoma. Gastro Hep Advances. Volume 2, Issue 3, 2023, Pages 307-321.

Same research area

Search Cancer