NJH-2-056 free base
NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) linking the OTUB1 recruiter EN523 to the CFTR chaperone lumacaftor.
For research use only. Not for human or veterinary use.
Research area
Inflammation/Immunology
Purity >98%
Stock Inquire
NJH-2-056 structure
CAS No.: 2858812-69-6
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 50 mg | USD 928.00 | BP-02393-50mg | In stock | Get quote |
| 100 mg | USD 1,385.00 | BP-02393-100mg | In stock | Get quote |
| 250 mg | USD 2,085.00 | BP-02393-250mg | In stock | Get quote |
| 500 mg | USD 2,985.00 | BP-02393-500mg | In stock | Get quote |
| 1 g | Inquire | BP-02393-1g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) linking the OTUB1 recruiter EN523 to the CFTR chaperone lumacaftor. NJH-2-056 can be used for cystic fibrosis research.
Identifiers
- SMILES
-
O=C(C=C)N1CC(=O)N(C=2OC(=CC2)CCC(=O)NCCCNC(=O)C3=CC=CC(=C3)C4=NC(=CC=C4C)NC(=O)C5(C6=CC=C7OC(F)(F)OC7=C6)CC5)CC1 - InChIKey
-
SXPTYNZPHCBSCJ-UHFFFAOYSA-N
Specifications
- MW (average)
- 782.7885
- Formula
- C41H40F2N6O8
- CAS No.
- 2858812-69-6
- Physical state
- Solid
- Color
- Off-white to pink
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month.
Solubility
Soluble in DMSO
- In vitro
- DMSO : ≥ 100 mg/mL
Documents
References
[1]. Henning NJ, et al. Deubiquitinase-targeting chimeras for targeted protein stabilization. Nat Chem Biol. 2022 Apr;18(4):412-421.