NJH-2-056 free base

NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) linking the OTUB1 recruiter EN523 to the CFTR chaperone lumacaftor.

For research use only. Not for human or veterinary use.

Target DUBTACs CFTR

Research area Inflammation/Immunology

Purity >98% Stock Inquire

Data Sheet SDS COA

NJH-2-056 structure

CAS No.: 2858812-69-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 928.00	BP-02393-50mg	In stock	Get quote
100 mg	USD 1,385.00	BP-02393-100mg	In stock	Get quote
250 mg	USD 2,085.00	BP-02393-250mg	In stock	Get quote
500 mg	USD 2,985.00	BP-02393-500mg	In stock	Get quote
1 g	Inquire	BP-02393-1g	In stock	Inquire

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Description

NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) linking the OTUB1 recruiter EN523 to the CFTR chaperone lumacaftor. NJH-2-056 can be used for cystic fibrosis research.

Identifiers

SMILES: O=C(C=C)N1CC(=O)N(C=2OC(=CC2)CCC(=O)NCCCNC(=O)C3=CC=CC(=C3)C4=NC(=CC=C4C)NC(=O)C5(C6=CC=C7OC(F)(F)OC7=C6)CC5)CC1
InChIKey: SXPTYNZPHCBSCJ-UHFFFAOYSA-N

Specifications

MW (average): 782.7885
Formula: C₄₁H₄₀F₂N₆O₈
CAS No.: 2858812-69-6
Physical state: Solid
Color: Off-white to pink
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month.

Solubility

Soluble in DMSO

In vitro: DMSO : ≥ 100 mg/mL

Documents

References

[1]. Henning NJ, et al. Deubiquitinase-targeting chimeras for targeted protein stabilization. Nat Chem Biol. 2022 Apr;18(4):412-421.

Same target

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Same research area

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