EG01377 2HCl other · Synonyms: EG01377 dihydrochloride

EG01377 dihydrochloride is a potent, bioavailable and selective inhibitor of neuropilin-1.

For research use only. Not for human or veterinary use.

Target Complement System

Research area Cancer

Purity 98+% Stock Inquire

Data Sheet SDS COA

EG01377 2HCl structure

CAS No.: 2749438-61-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 845.00	BP-02373A-100mg	In stock	Get quote
250 mg	USD 1,450.00	BP-02373A-250mg	In stock	Get quote
500 mg	USD 2,200.00	BP-02373A-500mg	In stock	Get quote
1 g	Inquire	BP-02373A-1g	In stock	Inquire

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Related forms

BP-02373 — EG01377

Description

EG01377 dihydrochloride is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1), with a Kd of 1.32 μM, and IC50s of 609 nM for both NRP1-a1 and NRP1-b1. EG01377 dihydrochloride has antiangiogenic, antimigratory, and antitumor effects.

Biological activity

In Vivo EG01377 (2 mg/kg; i.v.) exhibits an encouraging half-life of 4.29 h, sufficient to sustain once per day dosing in mice

Identifiers

SMILES: O=S(C1=CC(C2=CC=C(CN)C=C2)=CC3=C1OCC3)(NC4=C(C(N[C@@H](CCC/N=C(N)/N)C(O)=O)=O)SC=C4)=O.Cl.Cl
InChIKey: ZYFLTIBQQSYBQT-FJSYBICCSA-N

Specifications

MW (average): 659.6050
Formula: C₂₆H₃₂Cl₂N₆O₆S₂
CAS No.: 2749438-61-5
Physical state: Solid
Color: white to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: -20°C, stored under nitrogen, away from moisture

Solubility

Soluble in DMSO

In vitro: DMSO : 200 mg/mL

Documents

References

[1]. Powell J, et al. Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells. J Med Chem. 2018 May 10;61(9):4135-4154.

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