EG01377 free base · Synonyms: EG01377 free base

EG01377 is a potent, bioavailable and selective inhibitor of neuropilin-1.

For research use only. Not for human or veterinary use.

Target Complement System

Research area Cancer

Purity 98+% Stock Inquire

Data Sheet SDS COA

EG01377 structure

CAS No.: 2227996-00-9

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
10 mg	USD 498.00	BP-02373-10mg	In stock	Get quote
25 mg	USD 998.00	BP-02373-25mg	In stock	Get quote
50 mg	USD 1,680.00	BP-02373-50mg	In stock	Get quote
100 mg	USD 2,900.00	BP-02373-100mg	In stock	Get quote
250 mg	Inquire	BP-02373-250mg	In stock	Inquire

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Related forms

BP-02373A — EG01377 2HCl

Description

EG01377 is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1), with a Kd of 1.32 μM, and IC50s of both 609 nM for NRP1-a1 and NRP1-b1. EG01377 has antiangiogenic, antimigratory, and antitumor effects.

Biological activity

In Vivo EG01377 (2 mg/kg; i.v.) exhibits an encouraging half-life of 4.29 h, sufficient to sustain once per day dosing in mice

Identifiers

SMILES: C1COC2=C1C=C(C=C2S(=O)(=O)NC3=C(SC=C3)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C4=CC=C(C=C4)CN
InChIKey: SEXUXSMBJLNXIR-FQEVSTJZSA-N

Specifications

MW (average): 586.6830
Formula: C₂₆H₃₀N₆O₆S₂
CAS No.: 2227996-00-9
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO

In vitro: DMSO : 5 mg/mL

Documents

References

[1]. Powell J, et al. Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells. J Med Chem. 2018 May 10;61(9):4135-

Same research area

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