BiochemProbe — Life Science Research Reagents

AGI-41998 free base · Synonyms: AGI 41998 · AGI41998

AGI-41998 is a potent inhibitor of methionine adenosyltransferase 2A.

For research use only. Not for human or veterinary use.

Purity >98% Stock Inquire

AGI-41998 structure

CAS No.: 2377492-26-5

Download structure (.mol)

Pack sizes & pricing

Size Price SKU Stock
50 mg USD 900.00 BP-02270-50mg In stock Get quote
100 mg USD 1,350.00 BP-02270-100mg In stock Get quote
250 mg USD 1,950.00 BP-02270-250mg In stock Get quote
1 g USD 3,880.00 BP-02270-1g In stock Get quote
2 g Inquire BP-02270-2g In stock Inquire
5 g Inquire BP-02270-5g In stock Inquire

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Description

AGI-41998 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A). AGI-41998 is a brain-penetrant compound. AGI-41998 has the potential for exploring the effects of SAM modulation in the central nervous system (CNS) and research of cancer disease.

Biological activity

AGI-41998 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A). AGI-41998 is a brain-penetrant compound. AGI-41998 has the potential for exploring the effects of SAM modulation in the central nervous system (CNS) and research of cancer disease.

Identifiers

SMILES
COC1=CC=C(C=C1)N2C=C3C=NC(=NC3=C(C2=O)C4=CC=C(C=C4)Br)NCC(F)(F)F
InChIKey
QHXQQFITXAUNPR-UHFFFAOYSA-N

Specifications

MW (average)
505.2870
Formula
C22H16BrF3N4O2
CAS No.
2377492-26-5
Physical state
Solid
Color
light yellow to yellow
Shipping
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage
Powder -20℃, 3 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro
DMSO 83.33 mg/mL

References

[1]. Li M, et al. Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads. J Med Chem. 2022;65(6):4600-4615.

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