IDE397 free base · Synonyms: GSK-4362676 | MAT2A-IN-9
IDE397 is a potent inhibitor of MAT2A.
For research use only. Not for human or veterinary use.
Purity >98%
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IDE397 structure
CAS No.: 2439277-80-0
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 50 mg | USD 500.00 | BP-02018-50mg | In stock | Get quote |
| 100 mg | USD 680.00 | BP-02018-100mg | In stock | Get quote |
| 250 mg | USD 960.00 | BP-02018-250mg | In stock | Get quote |
| 500 mg | USD 1,350.00 | BP-02018-500mg | In stock | Get quote |
| 1 g | USD 1,850.00 | BP-02018-1g | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
IDE397 (GSK-4362676) is a potent inhibitor of MAT2A(methionine adenosyltransferase 2A) and exhibits anti-tumor activity in MTAP-deleted PDX models.
Identifiers
- SMILES
-
C1=CC=C(C(=C1)N2C3=C(C=CC(=N3)C(F)(F)F)C(=NC2=O)N)Cl - InChIKey
-
BVNKURJMNQNVAO-UHFFFAOYSA-N
Specifications
- MW (average)
- 340.6880
- Formula
- C14H8ClF3N4O
- CAS No.
- 2439277-80-0
- Physical state
- Solid
- Color
- White to Yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 3 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO, not in water
Documents
References
[1]. Marcus M. Fischer, Neil Bhola, John Faulhaber, Yevgeniy Freyman, Bing Yao, Zineb Mounir, Mark R. Lackner, Claire Neilan. MAT2A inhibitor, IDE397, displays broad anti-tumor activity across a panel of MTAP-deleted patient-derived xenografts [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 1278.
[2]. Guo, Jiamin et al. “Targeting the methionine-methionine adenosyl transferase 2A- S -adenosyl methionine axis for cancer therapy.” Current opinion in oncology vol. 34,5 (2022): 546-551.