IDE397 free base · Synonyms: GSK-4362676 | MAT2A-IN-9

IDE397 is a potent inhibitor of MAT2A.

For research use only. Not for human or veterinary use.

Target Methionine Adenosyltransferase (MAT)

Purity >98% Stock Inquire

Data Sheet SDS COA

IDE397 structure

CAS No.: 2439277-80-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 500.00	BP-02018-50mg	In stock	Get quote
100 mg	USD 680.00	BP-02018-100mg	In stock	Get quote
250 mg	USD 960.00	BP-02018-250mg	In stock	Get quote
500 mg	USD 1,350.00	BP-02018-500mg	In stock	Get quote
1 g	USD 1,850.00	BP-02018-1g	In stock	Get quote

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Description

IDE397 (GSK-4362676) is a potent inhibitor of MAT2A(methionine adenosyltransferase 2A) and exhibits anti-tumor activity in MTAP-deleted PDX models.

Identifiers

SMILES: C1=CC=C(C(=C1)N2C3=C(C=CC(=N3)C(F)(F)F)C(=NC2=O)N)Cl
InChIKey: BVNKURJMNQNVAO-UHFFFAOYSA-N

Specifications

MW (average): 340.6880
Formula: C₁₄H₈ClF₃N₄O
CAS No.: 2439277-80-0
Physical state: Solid
Color: White to Yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO, not in water

Documents

References

[1]. Marcus M. Fischer, Neil Bhola, John Faulhaber, Yevgeniy Freyman, Bing Yao, Zineb Mounir, Mark R. Lackner, Claire Neilan. MAT2A inhibitor, IDE397, displays broad anti-tumor activity across a panel of MTAP-deleted patient-derived xenografts [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 1278.

[2]. Guo, Jiamin et al. “Targeting the methionine-methionine adenosyl transferase 2A- S -adenosyl methionine axis for cancer therapy.” Current opinion in oncology vol. 34,5 (2022): 546-551.

Same target

Search Methionine Adenosyltransferase (MAT)