BI-9787 free base · Synonyms: BI 9787 · BI9787

BI-9787 is a zwitterionic inhibitior for ketohexokinase, with an IC50 of 12 and 12.8 nM for hKHK-A and hKHK-C.

For research use only. Not for human or veterinary use.

Target Ketohexokinase

Research area Metabolic Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

BI-9787 structure

CAS No.: 3043939-18-7

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 600.00	BP-02264-100mg	In stock	Get quote
250 mg	USD 1,100.00	BP-02264-250mg	In stock	Get quote
1 g	USD 2,150.00	BP-02264-1g	In stock	Get quote
5 g	Inquire	BP-02264-5g	In stock	Inquire

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Description

BI-9787 is a zwitterionic inhibitior for ketohexokinase, with an IC50 of 12 and 12.8 nM for hKHK-A and hKHK-C. BI-9787 exhibits good metabolic stability in rat hepatocyte and good pharmacokinetic characteristics in rats .

Identifiers

SMILES: CSC1=CC=C(C[C@@H](C(O)=O)C)C=C1NC2=C(C#N)C(C(F)F)=CC(N3CC[C@H](N(C)C)C3)=N2
InChIKey: LPDOIXPRZOWBJV-HOCLYGCPSA-N

Specifications

MW (average): 489.5810
Formula: C₂₄H₂₉F₂N₅O₂S
CAS No.: 3043939-18-7
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4℃, sealed storage, 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1]. Heine, Niklas et al. “Discovery of BI-9787, a potent zwitterionic ketohexokinase inhibitor with oral bioavailability.” Bioorganic & medicinal chemistry letters vol. 112 (2024): 129930. doi:10.1016/j.bmcl.2024.129930

Same research area

Search Metabolic Disease