NPC-15437 dihydrochloride salt form · dihydrochloride · Parent NPC-15437 dihydrochloride
NPC-15437 dihydrochloride is a selective, penetrable and reversible protein kinase C inhibitor.
For research use only. Not for human or veterinary use.
Target
PKC
Research area
Neurological Disease
Purity >98%
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NPC-15437 dihydrochloride structure
CAS No.: 141774-20-1
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 10 mg | USD 550.00 | BP-02188A-10mg | In stock | Get quote |
| 25 mg | USD 1,100.00 | BP-02188A-25mg | In stock | Get quote |
| 50 mg | USD 1,750.00 | BP-02188A-50mg | In stock | Get quote |
| 100 mg | USD 2,800.00 | BP-02188A-100mg | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
NPC-15437 dihydrochloride is a selective, penetrable and reversible protein kinase C (PKC) inhibitor, with an IC50 of 19 μM. NPC-15437 dihydrochloride interferes with mechanisms underlying memory consolidation .
Identifiers
- SMILES
-
NCCCC[C@H](N)C(NCC1N(CCCC1)C(CCCCCCCCCCCC)=O)=O.Cl.Cl - InChIKey
-
RISSBZWRJRRXTD-OLBPYZPGSA-N
Specifications
- MW (average)
- 511.6120
- Formula
- C25H52Cl2N4O2
- CAS No.
- 141774-20-1
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 month;
Solubility
soluble in DMSO
Documents
References
[1]. Mathis C, et al. The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice. Eur J Pharmacol. 1992 Sep 10;220(1):107-10.
[2]. Sullivan JP, et al. 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain. Mol Maheux, J., et al. Pharmacol. 1992 Jan;41(1):38-44.
[3]. Modulation of Nur77 expression by dopaminergic drug is altered by a MEK pathway inhibitor in vivo. The FASEB Journal, 20: A684-A685.