Bisindolylmaleimide IV free base

Bisindolylmaleimide IV is a potent protein kinase C inhibitor.

For research use only. Not for human or veterinary use.

Target PKC CMV

Research area Infection

Purity >98% Stock Inquire

Data Sheet SDS COA

Bisindolylmaleimide IV structure

CAS No.: 119139-23-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 410.00	BP-02412-100mg	In stock	Get quote
250 mg	USD 820.00	BP-02412-250mg	In stock	Get quote
500 mg	USD 1,312.00	BP-02412-500mg	In stock	Get quote
1 g	USD 2,100.00	BP-02412-1g	In stock	Get quote
2 g	USD 3,360.00	BP-02412-2g	In stock	Get quote
3 g	USD 4,030.00	BP-02412-3g	In stock	Get quote
5 g	Inquire	BP-02412-5g	In stock	Inquire

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Description

Bisindolylmaleimide IV (Arcyriarubin A) is a potent protein kinase C (PKC) inhibitor, with IC50s ranging from 0.1 to 0.55 μM. Bisindolylmaleimide IV also inhibits PKA (IC50=3.1-11.8μM) . Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with an IC50 of 0.2 μM .

Biological activity

In Vitro Bisindolylmaleimide IV (Arcyriarubin A) inhibits PKC with an IC50 of 0.1 μM in 1 % DMSO, while the IC50 of 0.55 μM in 10 % DMSO.

Identifiers

SMILES: O=C(C(C1=CNC2=C1C=CC=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O
InChIKey: DQYBRTASHMYDJG-UHFFFAOYSA-N

Specifications

MW (average): 327.3361
Formula: C₂₀H₁₃N₃O₂
CAS No.: 119139-23-0
Physical state: Solid
Color: Orange to red
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO : 125 mg/mL

Documents

References

[1].Davis PD, et al. Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84.

[2].Slater MJ, et al. Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. Bioorg Med Chem. 1999 Jun;7(6):1067-74.

Same target

Search PKC

Same research area

Search Infection