(S)-2-(4-(4-(4-(5-(1-amino-1-(4-fluorophenyl)ethyl)pyrimidin-2-yl)piperazin-1-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-1H-pyrazol-1-yl)ethan-1-ol free base · Synonyms: 2505078-08-8

A tyrosine kinase inhibitor.

For research use only. Not for human or veterinary use.

Target c-Kit

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

(S)-2-(4-(4-(4-(5-(1-amino-1-(4-fluorophenyl)ethyl)pyrimidin-2-yl)piperazin-1-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-1H-pyrazol-1-yl)ethan-1-ol structure

CAS No.: 2505078-08-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 500.00	BP-02026-250mg	In stock	Get quote
500 mg	USD 850.00	BP-02026-500mg	In stock	Get quote
1 g	USD 1,450.00	BP-02026-1g	In stock	Get quote

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Description

A tyrosine kinase inhibitor.

Biological activity

BLU 263, is a next-generation tyrosine kinase inhibitor (KIT) being developed by Blueprint Medicines for the treatment of indolent systemic mastocytosis (SM).

Identifiers

SMILES: OCCN1C=C(C=N1)C2=CN3N=CN=C(N4CCN(C5=NC=C([C@@](N)(C6=CC=C(C=C6)F)C)C=N5)CC4)C3=C2
InChIKey: IPMARPMXSFFZFG-MHZLTWQESA-N

Specifications

MW (average): 528.5840
Formula: C₂₇H₂₉FN₁₀O
CAS No.: 2505078-08-8
Physical state: Solid
Color: white to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Dave N, et al. Safety and pharmacokinetics of BLU-263, a next-generation KIT inhibitor, in healthy volunteers[C]//Cancer Res (AACR Annual Meeting Abstracts). 2021, 122.

[2]. Mariana Castells, et al. A Phase 2/3 Study of BLU-263 in Patients with Indolent Systemic Mastocytosis or Monoclonal Mast Cell Activation Syndrome. Allergy and Clinical Immunology. 2022, 149 (2).

Same target

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Same research area

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