BAY 2416964 free base · Synonyms: BAY-2416964 · BAY2416964

BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50…

For research use only. Not for human or veterinary use.

Target Aryl Hydrocarbon Receptor

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

BAY 2416964 structure

CAS No.: 2242464-44-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 385.00	BP-01994-100mg	In stock	Get quote
250 mg	USD 685.00	BP-01994-250mg	In stock	Get quote
500 mg	USD 1,085.00	BP-01994-500mg	In stock	Get quote
1 g	USD 1,585.00	BP-01994-1g	In stock	Get quote
5 g	Inquire	BP-01994-5g	Inquire	Inquire

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Description

BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50 of 341 nM. BAY 2416964 has the potential for solid tumors treatment.

Biological activity

In Vitro BAY 2416964 (Example 192) induces AHR-regulated gene CYP1A1 expression in a human monocytic U937 cells with an IC50 of 4.3 nM.

Identifiers

SMILES: O=C(C1=CC(C2=CC=C(Cl)C=C2)=NN(C3=CN(C)N=C3)C1=O)N[C@@H](C)CO
InChIKey: YAGSZKAJPHGVOV-NSHDSACASA-N

Specifications

MW (average): 387.8200
Formula: C₁₈H₁₈ClN₅O₃
CAS No.: 2242464-44-2
Physical state: Solid
Color: Light yellow to green yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Kober, Christina et al. “Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy.” Journal for immunotherapy of cancer vol. 11,11 (2023): e007495. doi:10.1136/jitc-2023-007495

[2]. Ilona GUTCHER, et al. 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides for the treatment of cancer. WO2018146010A1

Same target

Search Aryl Hydrocarbon Receptor

Same research area

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