NSC-703786 free base · Synonyms: 5F-203

5F-203 (NSC-703786) is a cytotoxic molecule that forms DNA adducts and cell cycle arrest.

For research use only. Not for human or veterinary use.

Target Aryl Hydrocarbon Receptor

Research area Others

Purity 98+% Stock Inquire

Data Sheet SDS COA

NSC-703786 structure

CAS No.: 260443-89-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 425.00	BP-02522-100mg	In stock	Get quote
250 mg	USD 675.00	BP-02522-250mg	In stock	Get quote
500 mg	USD 975.00	BP-02522-500mg	In stock	Get quote
1 g	USD 1,675.00	BP-02522-1g	In stock	Get quote
5 g	Inquire	BP-02522-5g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

5F-203 (NSC-703786) is a cytotoxic molecule that forms DNA adducts and cell cycle arrest. 5F-203 induces aryl hydrocarbon receptor (AhR) signaling and elevates expression of CYP1A1. 5F-203 also increases the levels of reactive oxygen species as well as activates JNK, ERK, and p38.

Identifiers

SMILES: FC1=CC=C(SC(C2=CC=C(N)C(C)=C2)=N3)C3=C1
InChIKey: IFWLHIIUGSEKKE-UHFFFAOYSA-N

Specifications

MW (average): 258.3140
Formula: C₁₄H₁₁FN₂S
CAS No.: 260443-89-8
Physical state: Solid
Color: Off-white to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1].Hutchinson I, et al. Antitumor benzothiazoles. 16. Synthesis and pharmaceutical properties of antitumor 2-(4-aminophenyl)benzothiazole amino acid prodrugs. J Med Chem. 2002 Jan 31;45(3):744-7.

[2].Hose CD, et al. Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4-amino-3-methylphenyl]-5-fluoro-benzothiazole: a potential surrogate marker for patient sensitivity. Mol Cancer Ther. 2003 Dec;2(12):1265-72.

[3].Callero MA, et al. Biomarkers of sensitivity to potent and selective antitumor 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F203) in ovarian cancer. J Cell Biochem. 2013 Oct;114(10):2392-404.

Same target

Search Aryl Hydrocarbon Receptor

Same research area

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